Correlating Information Contents of Gene Ontology Terms to Infer Semantic Similarity of Gene Products
المؤلف
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Successful applications of the gene ontology to the inference of functional relationships between gene products in recent years have raised the need for computational methods to automatically calculate semantic similarity between gene products based on semantic similarity of gene ontology terms.
Nevertheless, existing methods, though having been widely used in a variety of applications, may significantly overestimate semantic similarity between genes that are actually not functionally related, thereby yielding misleading results in applications.
To overcome this limitation, we propose to represent a gene product as a vector that is composed of information contents of gene ontology terms annotated for the gene product, and we suggest calculating similarity between two gene products as the relatedness of their corresponding vectors using three measures: Pearson’s correlation coefficient, cosine similarity, and the Jaccard index.
We focus on the biological process domain of the gene ontology and annotations of yeast proteins to study the effectiveness of the proposed measures.
Results show that semantic similarity scores calculated using the proposed measures are more consistent with known biological knowledge than those derived using a list of existing methods, suggesting the effectiveness of our method in characterizing functional relationships between gene products.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gan, Mingxin. 2014. Correlating Information Contents of Gene Ontology Terms to Infer Semantic Similarity of Gene Products. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-505880
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gan, Mingxin. Correlating Information Contents of Gene Ontology Terms to Infer Semantic Similarity of Gene Products. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-505880
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gan, Mingxin. Correlating Information Contents of Gene Ontology Terms to Infer Semantic Similarity of Gene Products. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-505880
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505880
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر