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The Effects of Remote Ischemic Preconditioning and N-Acetylcysteine with Remote Ischemic Preconditioning in Rat Hepatic Ischemia Reperfusion Injury Model
المؤلفون المشاركون
Guneli, Ensari
Ocmen, Elvan
Kume, Tuncay
Koca, Uğur
Unal Togrul, Belgin
Uysal, Ali Ihsan
Ergur, Bekir Ugur
Akan, Mert
Ozkardesler, Sevda
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Remote ischemic preconditioning (RIP) and pharmacological preconditioning are the effective methods that can be used to prevent ischemia reperfusion (IR) injury.
The aim of this study was to evaluate the effects of RIP and N-Acetylcysteine (NAC) with RIP in the rat hepatic IR injury model.
Materials and Methods.
28 rats were divided into 4 groups.
Group I (sham): only laparotomy was performed.
Group II (IR): following 30 minutes of hepatic pedicle occlusion, 4 hours of reperfusion was performed.
Group III (RIP + IR): following 3 cycles of RIP, hepatic IR was performed.
Group IV (RIP + NAC + IR): following RIP and intraperitoneal administration of NAC (150 mg/kg), hepatic IR was performed.
All the rats were sacrificed after blood samples were taken for the measurements of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and liver was processed for conventional histopathology.
Results.
The hepatic histopathological injury scores of RIP + IR and RIP + NAC + IR groups were significantly lower than IR group (P=0.006, P=0.003, resp.).
There were no significant differences in AST and ALT values between the IR, RIP + IR, and RIP + NAC + IR groups.
Conclusions.
In the present study, it was demonstrated histopathologically that RIP and RIP + NAC decreased hepatic IR injury significantly.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uysal, Ali Ihsan& Ocmen, Elvan& Akan, Mert& Ozkardesler, Sevda& Ergur, Bekir Ugur& Guneli, Ensari…[et al.]. 2014. The Effects of Remote Ischemic Preconditioning and N-Acetylcysteine with Remote Ischemic Preconditioning in Rat Hepatic Ischemia Reperfusion Injury Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-505950
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uysal, Ali Ihsan…[et al.]. The Effects of Remote Ischemic Preconditioning and N-Acetylcysteine with Remote Ischemic Preconditioning in Rat Hepatic Ischemia Reperfusion Injury Model. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-505950
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uysal, Ali Ihsan& Ocmen, Elvan& Akan, Mert& Ozkardesler, Sevda& Ergur, Bekir Ugur& Guneli, Ensari…[et al.]. The Effects of Remote Ischemic Preconditioning and N-Acetylcysteine with Remote Ischemic Preconditioning in Rat Hepatic Ischemia Reperfusion Injury Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-505950
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505950
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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