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Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes
المؤلفون المشاركون
Paolisso, Pasquale
Canonico, Silvestro
Padovano, Vincenzo
Barbieri, Michelangela
Ferraraccio, Franca
Petronella, Pasquale
Campitiello, Ferdinando
Marfella, Raffaele
Paolisso, Giuseppe
Petrella, Antonello
Canonico, Raffaele
Carbonara, Ornella
Gualdiero, Pasquale
Rizzo, Maria Rosaria
Sasso, Ferdinando Carlo
Della Corte, Angela
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The pathophysiology of chronic diabetic ulcers is complex and still incompletely understood, both micro- and macroangiopathy strongly contribute to the development and delayed healing of diabetic wounds, through an impaired tissue feeding and response to ischemia.
With adequate treatment, some ulcers may last only weeks; however, many ulcers are difficult to treat and may last months, in certain cases years; 19–35% of ulcers are reported as nonhealing.
As no efficient therapy is available, it is a high priority to develop new strategies for treatment of this devastating complication.
Because experimental and pathological studies suggest that incretin hormone glucagon-like peptide-1 may improves VEGF generation and promote the upregulation of HIF-1α through a reduction of oxidative stress, the study evaluated the effect of the augmentation of GLP-1, by inhibitors of the dipeptidyl peptidase-4, such as vildagliptin, on angiogenesis process and wound healing in diabetic chronic ulcers.
Although elucidation of the pathophysiologic importance of these aspects awaits further confirmations, the present study evidences an additional aspect of how DPP-4 inhibition might contribute to improved ulcer outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marfella, Raffaele& Sasso, Ferdinando Carlo& Rizzo, Maria Rosaria& Paolisso, Pasquale& Barbieri, Michelangela& Padovano, Vincenzo…[et al.]. 2012. Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-505951
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marfella, Raffaele…[et al.]. Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes. Experimental Diabetes Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-505951
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marfella, Raffaele& Sasso, Ferdinando Carlo& Rizzo, Maria Rosaria& Paolisso, Pasquale& Barbieri, Michelangela& Padovano, Vincenzo…[et al.]. Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-505951
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505951
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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