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Peripheral Mononuclear Cell Resistin mRNA Expression Is Increased in Type 2 Diabetic Women
المؤلفون المشاركون
Tsigos, Constantine
Souvatzoglou, Emmanouil
Kyrou, Ioannis
Yfanti, Eleni
Boutati, Eleni
Anastasiou, Eleni
Tsiotra, Panayoula C.
Raptis, Sotirios A.
المصدر
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-12-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Resistin has been shown to cause insulin resistance and to impair glucose tolerance in rodents, but in humans its physiological role still remains elusive.
The aim of this study was to examine whether resistin mRNA expression in human peripheral mononuclear cells (PBMCs) and its corresponding plasma levels are altered in type 2 diabetes.
Resistin mRNA levels were easily detectable in human PBMC, and found to be higher in DM2 compared to healthy women (P=.05).
Similarly, mononuclear mRNA levels of the proinflammatory cytokines IL-1β, TNF-α, and IL-6 were all significantly higher in DM2 compared to control women (P<.001).
The corresponding plasma resistin levels were slightly, but not significantly, increased in DM2 women (P=.051), and overall, they correlated significantly with BMI (r=0.406, P=.010) and waist circumference (r=0.516, P=.003), but not with fasting insulin levels or HOMA-IR.
Resistin mRNA expression is increased in PBMC from DM2 women, together with increased expression of the inflammatory cytokines IL-1β, TNF-α, and IL-6, independent of obesity.
These results suggest that resistin and cytokines might contribute to the low-grade inflammation and the increased atherogenic risk observed in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsiotra, Panayoula C.& Tsigos, Constantine& Anastasiou, Eleni& Yfanti, Eleni& Boutati, Eleni& Souvatzoglou, Emmanouil…[et al.]. 2008. Peripheral Mononuclear Cell Resistin mRNA Expression Is Increased in Type 2 Diabetic Women. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-505965
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsiotra, Panayoula C.…[et al.]. Peripheral Mononuclear Cell Resistin mRNA Expression Is Increased in Type 2 Diabetic Women. Mediators of Inflammation No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-505965
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsiotra, Panayoula C.& Tsigos, Constantine& Anastasiou, Eleni& Yfanti, Eleni& Boutati, Eleni& Souvatzoglou, Emmanouil…[et al.]. Peripheral Mononuclear Cell Resistin mRNA Expression Is Increased in Type 2 Diabetic Women. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-505965
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-505965
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