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Inhibitory Effects of PC-SPESII Herbal Extract on Human Breast Cancer Metastasis
المؤلفون المشاركون
Lu, Yi-yu
Zhang, Hui
Wang, Xiu-feng
Zhang, Tian-ling
Du, Jia
Su, Shi-Bing
Zhou, Qian-mei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Cancer metastasis is refractory to most forms of chemotherapy.
Conventional and alternative drugs, such as Chinese herbal remedies, have been developed to target metastatic cancer cells.
In this study, we investigated the effects of PC-SPESII, an herbal formulation, on the migration, invasion, and metastasis of an experimental human breast cancer cell line in vivo and in vitro.
PC-SPESII suppressed pulmonary metastasis and tumor growth of MDA-MB-231 human breast cancer xenografts without affecting body weight, liver function, and kidney function.
PC-SPESII also inhibited MDA-MB-231 cell migration and invasion in vitro in a dose-dependent manner.
Based on ELISA analysis, secretion of MMP-2 and MMP-9, proteins associated with extracellular matrix degradation, was reduced in response to PC-SPESII treatment.
Western blot analysis of whole-cell extracts revealed that the levels of proteolytic proteins associated with matrix and base membrane degradation (MMP-2, MMP-9, and uPA) were decreased and the levels of their endogenous inhibitors (TIMP1 and TIMP2) were increased.
Moreover, the p38MAPK and SAPK/JNK signaling pathway, which stimulates proteolytic enzymes and matrix degradation, was inhibited by PC-PSESII.
Remarkably, cotreatment with PC-PSESII and p38MAPK or SAPK/JNK inhibitors magnified the antimetastatic phenotype.
Our results indicate that PC-PSESII impairs human breast cancer metastasis by regulating proteolytic enzymes and matrix dynamics through the p38MAPK and SAPK/JNK pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xiu-feng& Du, Jia& Zhang, Tian-ling& Zhou, Qian-mei& Lu, Yi-yu& Zhang, Hui…[et al.]. 2013. Inhibitory Effects of PC-SPESII Herbal Extract on Human Breast Cancer Metastasis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-506110
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xiu-feng…[et al.]. Inhibitory Effects of PC-SPESII Herbal Extract on Human Breast Cancer Metastasis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-506110
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xiu-feng& Du, Jia& Zhang, Tian-ling& Zhou, Qian-mei& Lu, Yi-yu& Zhang, Hui…[et al.]. Inhibitory Effects of PC-SPESII Herbal Extract on Human Breast Cancer Metastasis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-506110
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506110
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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