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Improving Total-CholesterolHDL-Cholesterol Ratio Results in an Endothelial Dysfunction Recovery in Peripheral Artery Disease Patients
المؤلفون المشاركون
Varela, César
Esparza, Leticia
Bleda, Silvia
Rodriguez, Javier
Acin, Francisco
de Haro, Joaquín
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aims.
To evaluate the effects of variations of total-cholesterol/HDL-cholesterol ratio and the effects of the atorvastatin on endothelial function in peripheral artery disease (PAD).
Material and Methods.
A prospective, randomised controlled study was carried out in 150 PAD patients.
Patients randomized to the control group (n=75) were treated with antiplatelet drugs, angiotensin-converting-enzyme inhibitors and cardiovascular-risk-factor control.
Experimental group (n=75) also received treatment with atorvastatin for a month.
It was determined baseline nitrite plasma levels and total-cholesterol/HDL-cholesterol ratio and after one month of treatment in both groups.
It was also analysed the correlation between the gradient of nitrite levels and the differential of total-cholesterol/HDL ratio in treatment group.
Results.
After a month, a reduction in nitrite levels was detected in treatment group (11.88±7.8 μM versus 5.7 ± 1.8 μM, P<0.0001).
It was shown a higher decrease in nitrite plasma levels in the atorvastatin group finding lower levels assessments (5.7 ± 1.8 μM versus 13.1 ± 9.1 μM, resp., P<0.001).
A significant reduction in total-cholesterol/HDL-cholesterol ratio was observed in statin group after treatment (P<0.0001).
A strong correlation was found between the gradient of nitrite levels and the differential of total-cholesterol/HDL-cholesterol ratio in atorvastatin group (r=0.7; P<0.001).
Conclusions.
Improvement of nitrite levels are associated with decreased total cholesterol/HDL ratio values in PAD patients treated with atorvastatin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bleda, Silvia& de Haro, Joaquín& Varela, César& Esparza, Leticia& Rodriguez, Javier& Acin, Francisco. 2012. Improving Total-CholesterolHDL-Cholesterol Ratio Results in an Endothelial Dysfunction Recovery in Peripheral Artery Disease Patients. Cholesterol،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-506184
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bleda, Silvia…[et al.]. Improving Total-CholesterolHDL-Cholesterol Ratio Results in an Endothelial Dysfunction Recovery in Peripheral Artery Disease Patients. Cholesterol No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-506184
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bleda, Silvia& de Haro, Joaquín& Varela, César& Esparza, Leticia& Rodriguez, Javier& Acin, Francisco. Improving Total-CholesterolHDL-Cholesterol Ratio Results in an Endothelial Dysfunction Recovery in Peripheral Artery Disease Patients. Cholesterol. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-506184
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506184
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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