Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy
المؤلفون المشاركون
Kojima-Koba, Yukiko
Chujo, Daisuke
Ito, Naoko
Kobayashi, Junji
Sugihara, Masako
Higashida, Haruhiro
Nohara, Atsushi
Yamagishi, Masakazu
Yagi, Kunimasa
Ohtsuji, Michio
Shintaku-Kubota, Miyuki
Takeda, Yoshiyu
Yamaaki, Naoto
المصدر
Experimental Diabetes Research
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-03-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims/hypothesis.
ADP-ribosyl-cyclase activity (ADPRCA) of CD38 and other ectoenzymes mainly generate cyclic adenosine 5'diphosphate-(ADP-) ribose (cADPR) as a second messenger in various mammalian cells, including pancreatic beta cells and peripheral blood mononuclear cells (PBMCs).
Since PBMCs contribute to the pathogenesis of diabetic nephropathy, ADPRCA of PBMCs could serve as a clinical prognostic marker for diabetic nephropathy.
This study aimed to investigate the connection between ADPRCA in PBMCs and diabetic complications.
Methods.
PBMCs from 60 diabetic patients (10 for type 1 and 50 for type 2) and 15 nondiabetic controls were fluorometrically measured for ADPRCA based on the conversion of nicotinamide guanine dinucleotide (NGD+) into cyclic GDP-ribose.
Results.
ADPRCA negatively correlated with the level of HbA1c (P=.040, R2=.073), although ADPRCA showed no significant correlation with gender, age, BMI, blood pressure, level of fasting plasma glucose and lipid levels, as well as type, duration, or medication of diabetes.
Interestingly, patients with nephropathy, but not other complications, presented significantly lower ADPRCA than those without nephropathy (P=.0198) and diabetes (P=.0332).
ANCOVA analysis adjusted for HbA1c showed no significant correlation between ADPRCA and nephropathy.
However, logistic regression analyses revealed that determinants for nephropathy were systolic blood pressure and ADPRCA, not HbA1c.
Conclusion/interpretation.
Decreased ADPRCA significantly correlated with diabetic nephropathy.
ADPRCA in PBMCs would be an important marker associated with diabetic nephropathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ohtsuji, Michio& Yagi, Kunimasa& Shintaku-Kubota, Miyuki& Kojima-Koba, Yukiko& Ito, Naoko& Sugihara, Masako…[et al.]. 2009. Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy. Experimental Diabetes Research،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-506393
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ohtsuji, Michio…[et al.]. Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy. Experimental Diabetes Research No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-506393
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ohtsuji, Michio& Yagi, Kunimasa& Shintaku-Kubota, Miyuki& Kojima-Koba, Yukiko& Ito, Naoko& Sugihara, Masako…[et al.]. Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy. Experimental Diabetes Research. 2009. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-506393
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506393
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر