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Efficacy and Safety of a New Formulation of Pancrelipase (Ultrase MT20) in the Treatment of Malabsorption in Exocrine Pancreatic Insufficiency in Cystic Fibrosis
المؤلفون المشاركون
Graff, Gavin R.
Kanga, Jamshed F.
Spénard, Jean
Nasr, Samya Z.
Konstan, Michael W.
Moffett, Kathryn
Strausbaugh, Steven D.
Siméon, Édith
Liou, Theodore G.
Grondin, Josée
Ahrens, Richard
Millard, Susan L.
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Pancreatic enzyme replacement therapy is the standard of care for treatment of malabsorption in patients with cystic fibrosis (CF) and exocrine pancreatic insufficiency (PI).
Aim.
To evaluate efficacy and safety of a new formulation of pancrelipase (Ultrase MT20) in patients with CF and PI.
Coefficients of fat absorption (CFA%) and nitrogen absorption (CNA%) were the main efficacy parameters.
Safety was evaluated by monitoring laboratory analyses, adverse events (AEs), and overall signs and symptoms.
Methods.
Patients (n=31) were randomized in a crossover design comparing this pancrelipase with placebo during 2 inpatient evaluation periods (6-7 days each).
Fat and protein/nitrogen ingestion and excretion were measured from food diaries and 72-hour stool collections.
CFA% and CNA% were calculated for each period and compared.
Results.
Twenty-four patients provided analyzable data.
This pancrelipase increased mean CFA% and CNA% (+34.7% and +25.7%, resp., P<.0001 for both), reduced stool frequency, and improved stool consistency compared with placebo.
Placebo-treated patients reported more AEs, with gastrointestinal symptoms being the most frequently reported AE.
Conclusions.
This pancrelipase is a safe and effective treatment for malabsorption associated with exocrine PI in patients with CF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Konstan, Michael W.& Liou, Theodore G.& Strausbaugh, Steven D.& Ahrens, Richard& Kanga, Jamshed F.& Graff, Gavin R.…[et al.]. 2010. Efficacy and Safety of a New Formulation of Pancrelipase (Ultrase MT20) in the Treatment of Malabsorption in Exocrine Pancreatic Insufficiency in Cystic Fibrosis. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-506450
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Konstan, Michael W.…[et al.]. Efficacy and Safety of a New Formulation of Pancrelipase (Ultrase MT20) in the Treatment of Malabsorption in Exocrine Pancreatic Insufficiency in Cystic Fibrosis. Gastroenterology Research and Practice No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-506450
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Konstan, Michael W.& Liou, Theodore G.& Strausbaugh, Steven D.& Ahrens, Richard& Kanga, Jamshed F.& Graff, Gavin R.…[et al.]. Efficacy and Safety of a New Formulation of Pancrelipase (Ultrase MT20) in the Treatment of Malabsorption in Exocrine Pancreatic Insufficiency in Cystic Fibrosis. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-506450
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506450
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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