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Sunitinib Combined with Angiotensin-2 Type-1 Receptor Antagonists Induces More Necrosis : A Murine Xenograft Model of Renal Cell Carcinoma
المؤلفون المشاركون
Dolley-Hitze, Thibault
Collet, Nicolas
Verhoest, Grégory
Lavenu, Audrey
Jouan, Florence
Oger, Emmanuel
Vigneau, Cécile
Rioux-Leclercq, Nathalie
Belaud-Rotureau, Marc-Antoine
Bensalah, Karim
Arlot-Bonnemains, Yannick
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Angiotensin-2 type-1 receptor antagonists not are only antihypertensive drugs but also can inhibit VEGF production.
We hypothesised that adding telmisartan to sunitinib could potentiate the antiangiogenic effects.
Material and Methods.
786-O cell lines were injected in nude mice.
After tumor development, mice were divided into 4 groups: the first was the control group (DMSO), the second group was treated with sunitinib alone, the third group was treated with telmisartan alone, and the fourth group was treated with the combination.
Drugs were orally administered every day for four weeks.
Animals were sacrificed after treatment.
Blood and tumor tissues were collected for analysis by immunohistochemistry, Western Blot, and ELISA methods.
Results.
All animals developed a ccRCC and ten in each group were treated.
Using a kinetic model, tumors tended to grow slower in the combination group compared to others (P=0.06).
Compared to sunitinib alone, the addition of telmisartan significantly increased tissue necrosis (P=0.038).
Central microvascular density decreased (P=0.0038) as well as circulating VEGF (P=0.003).
There was no significant variation in proliferation or apoptosis markers.
Conclusion.
The combination of sunitinib and telmisartan revealed an enhancement of the blockage of the VEGF pathway on renal tumor resulting in a decrease in neoangiogenesis and an increase in necrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Verhoest, Grégory& Dolley-Hitze, Thibault& Jouan, Florence& Belaud-Rotureau, Marc-Antoine& Oger, Emmanuel& Lavenu, Audrey…[et al.]. 2014. Sunitinib Combined with Angiotensin-2 Type-1 Receptor Antagonists Induces More Necrosis : A Murine Xenograft Model of Renal Cell Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506537
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Verhoest, Grégory…[et al.]. Sunitinib Combined with Angiotensin-2 Type-1 Receptor Antagonists Induces More Necrosis : A Murine Xenograft Model of Renal Cell Carcinoma. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-506537
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Verhoest, Grégory& Dolley-Hitze, Thibault& Jouan, Florence& Belaud-Rotureau, Marc-Antoine& Oger, Emmanuel& Lavenu, Audrey…[et al.]. Sunitinib Combined with Angiotensin-2 Type-1 Receptor Antagonists Induces More Necrosis : A Murine Xenograft Model of Renal Cell Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506537
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506537
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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