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Enhanced Transport Capabilities via Nanotechnologies : Impacting Bioefficacy, Controlled Release Strategies, and Novel Chaperones
المؤلفون المشاركون
Panagiotou, Thomai
Fisher, Robert J.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-26
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Emerging nanotechnologies have, and will continue to have, a major impact on the pharmaceutical industry.
Their influence on a drug's life cycle, inception to delivery, is rapidly expanding.
As the industry moves more aggressively toward continuous manufacturing modes, utilizing Process Analytical Technology (PAT) and Process Intensification (PI) concepts, the critical role of transport phenomena becomes elucidated.
The ability to transfer energy, mass, and momentum with directed purposeful outcomes is a worthwhile endeavor in establishing higher production rates more economically.
Furthermore, the ability to obtain desired drug properties, such as size, habit, and morphology, through novel manufacturing strategies permits unique formulation control for optimum delivery methodologies.
Bottom-up processing to obtain nano-sized crystals is an excellent example.
Formulation and delivery are intimately coupled in improving bio-efficacy at reduced loading and/or better controlled release capabilities, minimizing side affects and providing improved therapeutic interventions.
Innovative nanotechnology applications, such as simultaneous targeting, imaging and delivery to tumors, are now possible through use of novel chaperones.
Other examples include nanoparticles attachment to T-cells, release from novel hydrogel implants, and functionalized encapsulants.
Difficult tasks such as drug delivery to the brain via the blood brain barrier and/or the cerebrospinal fluid are now easier to accomplish.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Panagiotou, Thomai& Fisher, Robert J.. 2011. Enhanced Transport Capabilities via Nanotechnologies : Impacting Bioefficacy, Controlled Release Strategies, and Novel Chaperones. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-506632
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Panagiotou, Thomai& Fisher, Robert J.. Enhanced Transport Capabilities via Nanotechnologies : Impacting Bioefficacy, Controlled Release Strategies, and Novel Chaperones. Journal of Drug Delivery No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-506632
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Panagiotou, Thomai& Fisher, Robert J.. Enhanced Transport Capabilities via Nanotechnologies : Impacting Bioefficacy, Controlled Release Strategies, and Novel Chaperones. Journal of Drug Delivery. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-506632
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506632
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