The Association between Serological Biomarkers and Primary Sjogren’s Syndrome Associated with Peripheral Polyneuropathy
المؤلفون المشاركون
Chang, Ya-Ting
Tsai, Nai-Wen
Chiu, Wen-Chan
Cheng, Ben-Chung
Lu, Cheng-Hsien
Hsu, Che-Wei
Su, Yu-Jih
Huang, Chi-Ren
Chang, Wen-Neng
Su, Chih-Min
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background and Aim.
The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy of Sjogren’s syndrome (SJS) patients remain unsatisfactory.
This study aimed to determine the prognostic value of circulating autoantibodies levels in SJS patients with peripheral neuropathy.
Methods.
Two hundred and fifty serological positive (either anti-Ro or anti-La positive) SJS patients’ data were collected retrospectively.
The titers of autoantibodies, electrophysiology reports, and clinical manifestation were reviewed.
Results.
The prevalence rate of peripheral neuropathy is 7.2% in our study.
Regarding classification of peripheral neuropathy, 12 had mixed sensorimotor polyneuropathy, six had cranial neuropathy.
After stepwise logistic regression analysis, anti-β2 glycoprotein I (aβ2GP I) and perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) were significantly associated with peripheral neuropathy in serology positive SJS (P=0.01, P=0.046, resp.).
Conclusion.
The occurrence of peripheral neuropathy among SJS patients is not frequent and easily overlooked.
Our study demonstrated that aβ2GP I and p-ANCA levels may imply the danger of the occurrence of neuropathy in SJS patients, and they can be considered a biomarker that should be added to the panel of conventional autoantibody in SJS patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hsu, Che-Wei& Su, Yu-Jih& Chang, Wen-Neng& Tsai, Nai-Wen& Chiu, Wen-Chan& Cheng, Ben-Chung…[et al.]. 2014. The Association between Serological Biomarkers and Primary Sjogren’s Syndrome Associated with Peripheral Polyneuropathy. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-506642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hsu, Che-Wei…[et al.]. The Association between Serological Biomarkers and Primary Sjogren’s Syndrome Associated with Peripheral Polyneuropathy. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-506642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hsu, Che-Wei& Su, Yu-Jih& Chang, Wen-Neng& Tsai, Nai-Wen& Chiu, Wen-Chan& Cheng, Ben-Chung…[et al.]. The Association between Serological Biomarkers and Primary Sjogren’s Syndrome Associated with Peripheral Polyneuropathy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-506642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر