First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene
المؤلفون المشاركون
Merican, Amir Feisal
El-Harouni, Ashraf A.
Manwar Hussain, Muhammad Ramzan
Anwar, Yasir
al-Aama, Jumana Yousuf
Bundajji, Nabil S.
Ali Mohamoud, Hussein Sheikh
Asfour, Hani
Qasmi, Zaheer Ulhaq
Baig, Mukhtiar
Shaik, Noor Ahmad
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-04
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
GalNAc-T1, a key candidate of GalNac-transferases genes family that is involved in mucin-type O-linked glycosylation pathway, is expressed in most biological tissues and cell types.
Despite the reported association of GalNAc-T1 gene mutations with human disease susceptibility, the comprehensive computational analysis of coding, noncoding and regulatory SNPs, and their functional impacts on protein level, still remains unknown.
Therefore, sequence- and structure-based computational tools were employed to screen the entire listed coding SNPs of GalNAc-T1 gene in order to identify and characterize them.
Our concordant in silico analysis by SIFT, PolyPhen-2, PANTHER-cSNP, and SNPeffect tools, identified the potential nsSNPs (S143P, G258V, and Y414D variants) from 18 nsSNPs of GalNAc-T1.
Additionally, 2 regulatory SNPs (rs72964406 and #x26; rs34304568) were also identified in GalNAc-T1 by using FastSNP tool.
Using multiple computational approaches, we have systematically classified the functional mutations in regulatory and coding regions that can modify expression and function of GalNAc-T1 enzyme.
These genetic variants can further assist in better understanding the wide range of disease susceptibility associated with the mucin-based cell signalling and pathogenic binding, and may help to develop novel therapeutic elements for associated diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali Mohamoud, Hussein Sheikh& Manwar Hussain, Muhammad Ramzan& El-Harouni, Ashraf A.& Shaik, Noor Ahmad& Qasmi, Zaheer Ulhaq& Merican, Amir Feisal…[et al.]. 2014. First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-506790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali Mohamoud, Hussein Sheikh…[et al.]. First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-506790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali Mohamoud, Hussein Sheikh& Manwar Hussain, Muhammad Ramzan& El-Harouni, Ashraf A.& Shaik, Noor Ahmad& Qasmi, Zaheer Ulhaq& Merican, Amir Feisal…[et al.]. First Comprehensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human GalNAc-T1 Gene. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-506790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر