Cisplatin-Based Chemotherapy versus Cetuximab in Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer Treatment
المؤلفون المشاركون
Chu, Pen-Yuan
Hu, Ming-Hung
Chen, Ming-Huang
Chang, Peter Mu-Hsin
Lee, Tsung-Lun
Wang, Ling-Wei
Lu, Hsueh-Ju
Yang, Muh-Hwa
Tai, Shyh-Kuan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Purpose.
This study aimed to analyze survival, clinical responses, compliance, and adverse effects in locally advanced head and neck cancer (LAHNC) patients treated with split-dose cisplatin-based concurrent chemoradiation therapy (SD-CCRT) or cetuximab with concurrent radiation therapy (BioRT).
Materials and Methods.
We retrospectively evaluated 170 LAHNC patients diagnosed between January 1, 2009, and July 31, 2012: 116 received CCRT and 54 received BioRT.
Results.
Complete response rates were similar in the SD-CCRT and BioRT groups (63.8% versus 59.3%; P=0.807), and locoregional relapse rates were 18.1% and 13.0%, respectively (P=0.400).
The 3-year relapse-free survival rate was 65.8% in the SD-CCRT group and 65.5% in the BioRT group, respectively (P=0.647).
The 3-year overall survival rate was 78.5% in the SD-CCRT group and 70.9% in the BioRT group, respectively (P=0.879).
Hematologic side effects were significantly more frequent in the SD-CCRT than in the BioRT group.
Mucositis frequency was similar.
Conclusions.
Primary SD-CCRT and BioRT both showed good clinical response and survival.
Hematologic toxicities were more frequent, but tolerable, in the SD-CCRT group.
Both groups showed good compliance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Ming-Hung& Wang, Ling-Wei& Lu, Hsueh-Ju& Chu, Pen-Yuan& Tai, Shyh-Kuan& Lee, Tsung-Lun…[et al.]. 2014. Cisplatin-Based Chemotherapy versus Cetuximab in Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer Treatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506819
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Ming-Hung…[et al.]. Cisplatin-Based Chemotherapy versus Cetuximab in Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer Treatment. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-506819
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Ming-Hung& Wang, Ling-Wei& Lu, Hsueh-Ju& Chu, Pen-Yuan& Tai, Shyh-Kuan& Lee, Tsung-Lun…[et al.]. Cisplatin-Based Chemotherapy versus Cetuximab in Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer Treatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506819
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506819
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر