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Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment
المؤلفون المشاركون
Ruiz, Patricia
Fisher, Jeffrey
Blount, Benjamin
Mumtaz, Moiz
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الطب البشري
الملخص EN
Post-exposure risk assessment of chemical and environmental stressors is a public health challenge.
Linking exposure to health outcomes is a 4-step process: exposure assessment, hazard identification, dose response assessment, and risk characterization.
This process is increasingly adopting “in silico” tools such as physiologically based pharmacokinetic (PBPK) models to fine-tune exposure assessments and determine internal doses in target organs/tissues.
Many excellent PBPK models have been developed.
But most, because of their scientific sophistication, have found limited field application—health assessors rarely use them.
Over the years, government agencies, stakeholders/partners, and the scientific community have attempted to use these models or their underlying principles in combination with other practical procedures.
During the past two decades, through cooperative agreements and contracts at several research and higher education institutions, ATSDR funded translational research has encouraged the use of various types of models.
Such collaborative efforts have led to the development and use of transparent and user-friendly models.
The “human PBPK model toolkit” is one such project.
While not necessarily state of the art, this toolkit is sufficiently accurate for screening purposes.
Highlighted in this paper are some selected examples of environmental and occupational exposure assessments of chemicals and their mixtures.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mumtaz, Moiz& Fisher, Jeffrey& Blount, Benjamin& Ruiz, Patricia. 2012. Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-506841
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mumtaz, Moiz…[et al.]. Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment. Journal of Toxicology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-506841
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mumtaz, Moiz& Fisher, Jeffrey& Blount, Benjamin& Ruiz, Patricia. Application of Physiologically Based Pharmacokinetic Models in Chemical Risk Assessment. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-506841
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506841
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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