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Nitric Oxide Is a Mediator of Antiproliferative Effects Induced by Proinflammatory Cytokines on Pancreatic Beta Cells
المؤلفون المشاركون
Perez-Arana, Gonzalo
Aguilar-Diosdado, Manuel
Segundo, Carmen
Blandino-Rosano, Manuel
Lechuga-Sancho, Alfonso
Cebada-Aleu, Alberto
Quintana-Lopez, Laura
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Nitric oxide (NO) is involved in several biological processes.
In type 1 diabetes mellitus (T1DM), proinflammatory cytokines activate an inducible isoform of NOS (iNOS) in β cells, thus increasing NO levels and inducing apoptosis.
The aim of the current study is to determine the role of NO (1) in the antiproliferative effect of proinflammatory cytokines IL-1β, IFN-γ, and TNF-α on cultured islet β cells and (2) during the insulitis stage prior to diabetes onset using the Biobreeding (BB) rat strain as T1DM model.
Our results indicate that NO donors exert an antiproliferative effect on β cell obtained from cultured pancreatic islets, similar to that induced by proinflammatory cytokines.
This cytokine-induced antiproliferative effect can be reversed by L-NMMA, a general NOS inhibitor, and is independent of guanylate cyclase pathway.
Assays using NOS isoform specific inhibitors suggest that the NO implicated in the antiproliferative effect of proinflammatory cytokines is produced by inducible NOS, although not in an exclusive way.
In BB rats, early treatment with L-NMMA improves the initial stage of insulitis.
We conclude that NO is an important mediator of antiproliferative effect induced by proinflammatory cytokines on cultured β cell and is implicated in β-cell proliferation impairment observed early from initial stage of insulitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Quintana-Lopez, Laura& Blandino-Rosano, Manuel& Perez-Arana, Gonzalo& Cebada-Aleu, Alberto& Lechuga-Sancho, Alfonso& Aguilar-Diosdado, Manuel…[et al.]. 2013. Nitric Oxide Is a Mediator of Antiproliferative Effects Induced by Proinflammatory Cytokines on Pancreatic Beta Cells. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-506905
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Quintana-Lopez, Laura…[et al.]. Nitric Oxide Is a Mediator of Antiproliferative Effects Induced by Proinflammatory Cytokines on Pancreatic Beta Cells. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-506905
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Quintana-Lopez, Laura& Blandino-Rosano, Manuel& Perez-Arana, Gonzalo& Cebada-Aleu, Alberto& Lechuga-Sancho, Alfonso& Aguilar-Diosdado, Manuel…[et al.]. Nitric Oxide Is a Mediator of Antiproliferative Effects Induced by Proinflammatory Cytokines on Pancreatic Beta Cells. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-506905
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506905
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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