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EMMPRIN Expression in Oral Squamous Cell Carcinomas : Correlation with Tumor Proliferation and Patient Survival
المؤلفون المشاركون
Ricardo, Sara
Amaral, Barbas do
Monteiro, Luís Silva
Pacheco, José Júlio
Bousbaa, Hassan
Garcez, Fernanda
Delgado, Maria Leonor
Lopes, Carlos
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of our study was to explore the clinicopathological and prognostic significance of extracellular matrix metalloproteinase inducer (EMMPRIN) expression in oral squamous cell carcinomas (OSCC), and its relation with the proliferative tumor status of OSCC.
We examined EMMPRIN and Ki-67 proteins expression by immunohistochemistry in 74 cases with OSCC.
Statistical analysis was conducted to examine their clinicopathological and prognostic significance in OSCC.
EMMPRIN membrane expression was observed in all cases, with both membrane and cytoplasmic tumor expression in 61 cases (82.4%).
EMMPRIN overexpression was observed in 56 cases (75.7%).
Moderately or poorly differentiated tumors showed EMMPRIN overexpression more frequently than well-differentiated tumors (P=0.002).
Overexpression of EMMPRIN was correlated with high Ki-67 expression (P=0.004).
In the multivariate analysis, EMMPRIN overexpression reveals an adverse independent prognostic value for cancer-specific survival (CSS) (P=0.034).
Our results reveal that EMMPRIN protein is overexpressed in more than two-thirds of OSCC cases, especially in high proliferative and less differentiated tumors.
The independent value of EMMPRIN overexpression in CSS suggests that this protein could be used as an important biological prognostic marker for patients with OSCC.
Moreover, the high expression of EMMPRIN makes it a possible therapeutic target in OSCC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Monteiro, Luís Silva& Delgado, Maria Leonor& Ricardo, Sara& Garcez, Fernanda& Amaral, Barbas do& Pacheco, José Júlio…[et al.]. 2014. EMMPRIN Expression in Oral Squamous Cell Carcinomas : Correlation with Tumor Proliferation and Patient Survival. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506936
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Monteiro, Luís Silva…[et al.]. EMMPRIN Expression in Oral Squamous Cell Carcinomas : Correlation with Tumor Proliferation and Patient Survival. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-506936
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Monteiro, Luís Silva& Delgado, Maria Leonor& Ricardo, Sara& Garcez, Fernanda& Amaral, Barbas do& Pacheco, José Júlio…[et al.]. EMMPRIN Expression in Oral Squamous Cell Carcinomas : Correlation with Tumor Proliferation and Patient Survival. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506936
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506936
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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