Effects of Rosiglitazone with Insulin Combination Therapy on Oxidative Stress and Lipid Profile in Left Ventricular Muscles of Diabetic Rats
المؤلفون المشاركون
Kavak, Servet
Ayaz, Lokman
Emre, Mustafa
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
In this study, we tested the hypothesis that rosiglitazone (RSG) with insulin is able to quench oxidative stress initiated by high glucose through prevention of NAD(P)H oxidase activation.
Methods and Materials.
Male albino Wistar rats were randomly divided into an untreated control group (C), a diabetic group (D) that was treated with a single intraperitoneal injection of streptozotocin (45 mgkg−1), and rosiglitazone group that was treated with RSG twice daily by gavage and insulin once daily by subcutaneous injection (group B).
HbA1c and blood glucose levels in the circulation and malondialdehyde and 3-nitrotyrosine levels in left ventricular muscle were measured.
Result.
Treatment of D rats with group B resulted in a time-dependent decrease in blood glucose.
We found that the lipid profile and HbA1c levels in group B reached the control group D rat values at the end of the treatment period.
There was an increase in 3-nitrotyrosine levels in group D compared to group C.
Malondialdehyde and 3-nitrotyrosine levels were found to be decreased in group B compared to group D (P<0.05).
Conclusion.
Our data suggests that the treatment of diabetic rats with group B for 8 weeks may decrease the oxidative/nitrosative stress in left ventricular tissue of rats.
Thus, in diabetes-related vascular diseases, group B treatment may be cardioprotective.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kavak, Servet& Ayaz, Lokman& Emre, Mustafa. 2012. Effects of Rosiglitazone with Insulin Combination Therapy on Oxidative Stress and Lipid Profile in Left Ventricular Muscles of Diabetic Rats. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-506937
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kavak, Servet…[et al.]. Effects of Rosiglitazone with Insulin Combination Therapy on Oxidative Stress and Lipid Profile in Left Ventricular Muscles of Diabetic Rats. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-506937
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kavak, Servet& Ayaz, Lokman& Emre, Mustafa. Effects of Rosiglitazone with Insulin Combination Therapy on Oxidative Stress and Lipid Profile in Left Ventricular Muscles of Diabetic Rats. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-506937
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506937
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر