Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India
المؤلفون المشاركون
Kumar, N.
Ahmad, H.
Sinha, Sanjeev
Shekhar, R. C.
Samantaray, J. C.
Pandey, R. M.
Fahey, J. L.
Sharma, S. K.
Bhargava, A.
Dar, L.
Mitsuyasu, Ronald T.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
The increased use of antiretroviral therapy (ART) has reduced the morbidity and mortality associated with HIV, adversely leading to the emergence of HIV drug resistance (HIVDR).
In this study we aim to evaluate the prevalence of HIVDR mutations in ART-naive HIV-1 infected patients from northern India.
Design.
Analysis was performed using Viroseq genotyping system based on sequencing of entire protease and two-thirds of the Reverse Transcriptase (RT) region of pol gene.
Results.
Seventy three chronic HIV-1 infected ART naïve patients eligible for first line ART were enrolled from April 2006 to August 2008.
In 68 patients DNA was successfully amplified and sequencing was done.
97% of HIV-1 strains belonged to subtype C, and one each to subtype A1 and subtype B.
The overall prevalence of primary DRMs was 2.9% [2/68, 95% confidence interval (CI), 0.3%–10.2%].
One patient had a major RT mutation M184V, known to confer resistance to lamivudine, and another had a major protease inhibitor (PI) mutation D30N that imparts resistance to nelfinavir.
Conclusion.
Our study shows that primary HIVDR mutations have a prevalence of 2.9% among ART-naive chronic HIV-1 infected individuals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sinha, Sanjeev& Ahmad, H.& Shekhar, R. C.& Kumar, N.& Dar, L.& Samantaray, J. C.…[et al.]. 2012. Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-506953
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sinha, Sanjeev…[et al.]. Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India. AIDS Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-506953
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sinha, Sanjeev& Ahmad, H.& Shekhar, R. C.& Kumar, N.& Dar, L.& Samantaray, J. C.…[et al.]. Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-506953
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506953
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر