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Clinical Use of Cinacalcet in MEN1 Hyperparathyroidism
المؤلفون المشاركون
Akker, S. A.
Monson, J. P.
Moyes, V. J.
Chew, Shern L.
المصدر
International Journal of Endocrinology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-05-26
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background.
Management of multiple-endocrine neoplasia type 1- (MEN1-) associated hyperparathyroidism is associated with high recurrence rates and high surgical morbidity due to multiple neck explorations.
Cinacalcet, a calcimimetic agent licensed for the treatment of secondary hyperparathyroidism and parathyroid carcinoma, may provide a medical alternative for the management of these complex patients.
Methods.
A prospective audit was performed of eight patients; three males and five females, aged 20–38 at diagnosis.
Two patients commenced cinacalcet as primary treatment and six had previous surgery.
Six patients had complications of hyperparathyroidism: renal calculi, renal dysfunction, and reduced bone mineral density.
All were commenced on cinacalcet 30 mg bd for MEN1 associated hyperparathyroidism; doses were subsequently reduced to 30 mg od in four patients.
Results.
Significant reductions were observed in serum calcium and PTH measurements.
Serum calcium reduced by a median of 0.35 mmol/L (P=.012 Wilcoxon Signed Rank).
Serum PTH levels decreased by a median of 5.05 pmol/L (P=.012).
There was no change in urine calcium.
Duration ranged from 10–35 months with maintenance of control.
Cinacalcet was well tolerated by six patients; one experienced nausea and one experienced diarrhoea.
Conclusion.
Cinacalcet is an effective and well-tolerated medical treatment for the management of complex primary hyperparathyroidism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moyes, V. J.& Monson, J. P.& Chew, Shern L.& Akker, S. A.. 2010. Clinical Use of Cinacalcet in MEN1 Hyperparathyroidism. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-506985
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moyes, V. J.…[et al.]. Clinical Use of Cinacalcet in MEN1 Hyperparathyroidism. International Journal of Endocrinology No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-506985
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moyes, V. J.& Monson, J. P.& Chew, Shern L.& Akker, S. A.. Clinical Use of Cinacalcet in MEN1 Hyperparathyroidism. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-506985
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-506985
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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