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Anti-Inflammatory Effect of Qingpeng Ointment in Atopic Dermatitis-Like Murine Model
المؤلفون المشاركون
Li, Lin-Feng
Jiang, Wei
Li, Yun-Zhu
Lu, Xue-Yan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Qingpeng ointment (QP) is a Chinese medicine which has been used in treatment of atopic dermatitis (AD) in China.
AD-like lesions were induced in BALB/c mice by repeated application of 2,4-dinitrofluorobenzene (DNFB) on shaved backs.
The mice were then treated for 2 weeks with QP of different concentrations and Mometasone Furoate cream (MF), respectively.
Macroscopic and microscopic changes of the skin lesions were observed after the treatment.
The levels of serum immunoglobulin (Ig) E, tissue interferon (IFN)-γ, and interleukin (IL)-4 and IL-17A and the levels of involucrin, filaggrin, and kallikrein7 in epidermis were measured.
The results show severe dermatitis with immune profiles similar to human acute AD.
A significant infiltration of CD4+ T and mast cells was observed in dermis of lesion but inhibited by QP after a 2-week treatment with it.
The production of IgE, IL-4 and the mRNA expression of IL-17A were also suppressed, but the level of IFN-γ was increased.
MF suppressed all production of these cytokines and IgE.
Accordingly, the mechanism of QP on AD might correlate with its ability of modulating the immune dysfunctions rather than suppressing them.
It had no effect on expressions of involucrin and filaggrin, except that its vehicle decreased the level of kallikrein7.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yun-Zhu& Lu, Xue-Yan& Jiang, Wei& Li, Lin-Feng. 2013. Anti-Inflammatory Effect of Qingpeng Ointment in Atopic Dermatitis-Like Murine Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-507077
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yun-Zhu…[et al.]. Anti-Inflammatory Effect of Qingpeng Ointment in Atopic Dermatitis-Like Murine Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-507077
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yun-Zhu& Lu, Xue-Yan& Jiang, Wei& Li, Lin-Feng. Anti-Inflammatory Effect of Qingpeng Ointment in Atopic Dermatitis-Like Murine Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-507077
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507077
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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