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Histopathological Growth Pattern, Proteolysis and Angiogenesis in Chemonaive Patients Resected for Multiple Colorectal Liver Metastases
المؤلفون المشاركون
Laerum, Ole Didrik
Illemann, Martin
Høyer-Hansen, Gunilla
Wettergren, André
Vermeulen, Peter B.
Federspiel, Birgitte
Eefsen, Rikke Løvendahl
Vainer, Ben
Willemoe, Gro L.
Van den Eynden, Gert G.
Østerlind, Kell
Brodt, Pnina
Christensen, Ib Jarle
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The purpose of this study was to characterise growth patterns, proteolysis, and angiogenesis in colorectal liver metastases from chemonaive patients with multiple liver metastases.
Twenty-four patients were included in the study, resected for a median of 2.6 metastases.
The growth pattern distribution was 25.8% desmoplastic, 33.9% pushing, and 21% replacement.
In 20 patients, identical growth patterns were detected in all metastases, but in 8 of these patients, a second growth pattern was also present in one or two of the metastases.
In the remaining 4 patients, no general growth pattern was observed, although none of the liver metastases included more than two growth patterns.
Overall, a mixed growth pattern was demonstrated in 19.3% of the liver metastases.
Compared to metastases with pushing, those with desmoplastic growth pattern had a significantly up-regulated expression of urokinase-type plasminogen activator receptor (P=0.0008).
Angiogenesis was most pronounced in metastases with a pushing growth pattern in comparison to those with desmoplastic (P=0.0007) and replacement growth pattern (P=0.021).
Although a minor fraction of the patients harboured metastases with different growth patterns, we observed a tendency toward growth pattern uniformity in the liver metastases arising in the same patient.
The result suggests that the growth pattern of liver metastases is not a random phenomenon.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eefsen, Rikke Løvendahl& Van den Eynden, Gert G.& Høyer-Hansen, Gunilla& Brodt, Pnina& Laerum, Ole Didrik& Vermeulen, Peter B.…[et al.]. 2012. Histopathological Growth Pattern, Proteolysis and Angiogenesis in Chemonaive Patients Resected for Multiple Colorectal Liver Metastases. Journal of Oncology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-507178
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eefsen, Rikke Løvendahl…[et al.]. Histopathological Growth Pattern, Proteolysis and Angiogenesis in Chemonaive Patients Resected for Multiple Colorectal Liver Metastases. Journal of Oncology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-507178
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eefsen, Rikke Løvendahl& Van den Eynden, Gert G.& Høyer-Hansen, Gunilla& Brodt, Pnina& Laerum, Ole Didrik& Vermeulen, Peter B.…[et al.]. Histopathological Growth Pattern, Proteolysis and Angiogenesis in Chemonaive Patients Resected for Multiple Colorectal Liver Metastases. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-507178
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507178
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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