Cellular Transplantation Alters the Disease Progression in Becker’s Muscular Dystrophy
المؤلفون المشاركون
Sane, Hemangi
Paranjape, Amruta
Bhagawanani, Khushboo
Gokulchandran, Nandini
Sharma, Alok
Badhe, Prerna
المصدر
Case Reports in Transplantation
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Becker’s Muscular Dystrophy (BMD) is a dystrophinopathy manifested as progressive muscle degeneration.
Autologous Bone Marrow Mononuclear Cells (BMMNCs) have shown some myogenic potential.
The paracrine effects of the BMMNCs reduce the inflammation and are thought to reduce muscle degeneration.
We treated a 39 year old dental surgeon suffering from BMD.
Muscle strength was reduced when measured using modified Medical Research Council’s Manual Muscle Testing (mMRC-MMT).
Static sitting balance was poor.
He was wheelchair dependent for ambulation and moderately independent in Activities of Daily Living (ADL).
Functional Independence Measure (FIM) score was 93.
Musculoskeletal Magnetic Resonance Imaging (MRI-MSK) showed moderate fatty infiltration in the muscles.
Three cellular transplantations were carried out.
Clinical assessment and the investigations were repeated.
Progressive increase in the muscle strength was noted.
Ambulation was independent using push-knee splints and minimal assistance when weary.
Static and dynamic balance in sitting and standing improved.
FIM score increased from 93 to 105.
There was no increase in the degree of fatty infiltration, as seen on the MRI-MSK.
The case study provides evidence for the putative benefits of cellular therapy in altering the disease progression in BMD.
It also suggests augmented clinical benefits of combination of cellular therapy and rehabilitation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharma, Alok& Paranjape, Amruta& Sane, Hemangi& Bhagawanani, Khushboo& Gokulchandran, Nandini& Badhe, Prerna. 2013. Cellular Transplantation Alters the Disease Progression in Becker’s Muscular Dystrophy. Case Reports in Transplantation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-507304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharma, Alok…[et al.]. Cellular Transplantation Alters the Disease Progression in Becker’s Muscular Dystrophy. Case Reports in Transplantation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-507304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharma, Alok& Paranjape, Amruta& Sane, Hemangi& Bhagawanani, Khushboo& Gokulchandran, Nandini& Badhe, Prerna. Cellular Transplantation Alters the Disease Progression in Becker’s Muscular Dystrophy. Case Reports in Transplantation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-507304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر