Simvastatin Combined with Antioxidant Attenuates the Cerebral Vascular Endothelial Inflammatory Response in a Rat Traumatic Brain Injury

المؤلفون المشاركون

Cho, Chung-Lung
Lu, Kang
Wang, Hao-Kuang
Liang, Cheng-Loong
Chen, Han-Jung
Tsai, Yu-Duan
Liliang, Po-Chou
Wang, Kuo-Wei

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-06-11

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Traumatic brain injury (TBI) leads to important and deleterious neuroinflammation, as evidenced by indicators such as edema, cytokine production, induction of nitric oxide synthase, and leukocyte infiltration.

After TBI, cerebral vascular endothelial cells play a crucial role in the pathogenesis of inflammation.

In our previous study, we proved that simvastatin could attenuate cerebral vascular endothelial inflammatory response in a rat traumatic brain injury.

This purpose of this study was to determine whether simvastatin combined with an antioxidant could produce the same effect or greater and to examine affected surrogate biomarkers for the neuroinflammation after traumatic brain injury in rat.

In our study, cortical contusions were induced, and the effect of acute and continuous treatment of simvastatin and vitamin C on behavior and inflammation in adult rats following experimental TBI was evaluated.

The results demonstrated that simvastatin combined with an antioxidant could provide neuroprotection and it may be attributed to a dampening of cerebral vascular endothelial inflammatory response.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Kuo-Wei& Wang, Hao-Kuang& Chen, Han-Jung& Liliang, Po-Chou& Liang, Cheng-Loong& Tsai, Yu-Duan…[et al.]. 2014. Simvastatin Combined with Antioxidant Attenuates the Cerebral Vascular Endothelial Inflammatory Response in a Rat Traumatic Brain Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-507372

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Kuo-Wei…[et al.]. Simvastatin Combined with Antioxidant Attenuates the Cerebral Vascular Endothelial Inflammatory Response in a Rat Traumatic Brain Injury. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-507372

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Kuo-Wei& Wang, Hao-Kuang& Chen, Han-Jung& Liliang, Po-Chou& Liang, Cheng-Loong& Tsai, Yu-Duan…[et al.]. Simvastatin Combined with Antioxidant Attenuates the Cerebral Vascular Endothelial Inflammatory Response in a Rat Traumatic Brain Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-507372

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-507372