Cognitive Profiles in Parkinson’s Disease and Their Relation to Dementia : A Data-Driven Approach
المؤلفون المشاركون
Fruhmann Berger, Monika
Huber, Heiko
Brockmann, Kathrin
Srulijes, Karin
Gaenslen, Alexandra
Berg, Daniela
Feseker, Anne
Liepelt-Scarfone, Inga
Csoti, Ilona
Godau, Jana
Graeber, Susanne
Baysal, Gülsüm
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Parkinson’s disease is characterized by a substantial cognitive heterogeneity, which is apparent in different profiles and levels of severity.
To date, a distinct clinical profile for patients with a potential risk of developing dementia still has to be identified.
We introduce a data-driven approach to detect different cognitive profiles and stages.
Comprehensive neuropsychological data sets from a cohort of 121 Parkinson’s disease patients with and without dementia were explored by a factor analysis to characterize different cognitive domains.
Based on the factor scores that represent individual performance in each domain, hierarchical cluster analyses determined whether subgroups of Parkinson’s disease patients show varying cognitive profiles.
A six-factor solution accounting for 65.2% of total variance fitted best to our data and revealed high internal consistencies (Cronbach’s alpha coefficients >0.6).
The cluster analyses suggested two independent patient clusters with different cognitive profiles.
They differed only in severity of cognitive impairment and self-reported limitation of activities of daily living function but not in motor performance, disease duration, or dopaminergic medication.
Based on a data-driven approach, divers cognitive profiles were identified, which separated early and more advanced stages of cognitive impairment in Parkinson’s disease without dementia.
Importantly, these profiles were independent of motor progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liepelt-Scarfone, Inga& Graeber, Susanne& Fruhmann Berger, Monika& Feseker, Anne& Baysal, Gülsüm& Csoti, Ilona…[et al.]. 2012. Cognitive Profiles in Parkinson’s Disease and Their Relation to Dementia : A Data-Driven Approach. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-507427
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liepelt-Scarfone, Inga…[et al.]. Cognitive Profiles in Parkinson’s Disease and Their Relation to Dementia : A Data-Driven Approach. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-507427
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liepelt-Scarfone, Inga& Graeber, Susanne& Fruhmann Berger, Monika& Feseker, Anne& Baysal, Gülsüm& Csoti, Ilona…[et al.]. Cognitive Profiles in Parkinson’s Disease and Their Relation to Dementia : A Data-Driven Approach. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-507427
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507427
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر