Impact of Molecular Testing in the Diagnosis of Thyroid Fine Needle Aspiration Cytology : Data from Mainland China
المؤلفون المشاركون
Pan, Qin-jing
Guo, Hui-qin
Zhao, Huan
Zhang, Zhi-hui
Xiao, Ting
Zhu, Yan-li
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-29
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The molecular work-up of thyroid nodules from fine needle aspiration samples has given clinicians a new level of diagnostic information.
The aim of the present study was to evaluate the utility of molecular analysis in thyroid fine needle aspiration samples from a Chinese population.
Methods.
Specimens were collected from thyroid nodules by fine needle aspiration.
Cytology diagnosis and genes analysis were performed and correlated with histology outcome.
Results.
A total of 83 patients with thyroid nodules were enrolled, including 20 benign lesions and 63 papillary carcinomas.
BRAF and RAS mutations and RET/PTC gene rearrangements were found in 65.1%, 0%, and 1.6% of papillary carcinomas, respectively.
No gene alterations were found in benign lesions.
The combination of BRAF testing and cytology improved the accuracy of cytology from 69.9% to 89.2% (P<0.05).
Moreover, BRAF testing confirmed 82.4% of papillary carcinomas with suspicious cytology and identified 33.3% of papillary carcinomas with atypia cytology.
Conclusions.
Of the three candidate markers, BRAF testing showed diagnostic utility in fine needle aspiration.
Combining BRAF testing with cytology improves the accuracy of fine needle biopsy.
Those who have positive BRAF and malignant or suspicious malignant cytology can undergo thyroidectomy without a frozen section.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Hui-qin& Zhao, Huan& Zhang, Zhi-hui& Zhu, Yan-li& Xiao, Ting& Pan, Qin-jing. 2014. Impact of Molecular Testing in the Diagnosis of Thyroid Fine Needle Aspiration Cytology : Data from Mainland China. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-507471
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Hui-qin…[et al.]. Impact of Molecular Testing in the Diagnosis of Thyroid Fine Needle Aspiration Cytology : Data from Mainland China. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-507471
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Hui-qin& Zhao, Huan& Zhang, Zhi-hui& Zhu, Yan-li& Xiao, Ting& Pan, Qin-jing. Impact of Molecular Testing in the Diagnosis of Thyroid Fine Needle Aspiration Cytology : Data from Mainland China. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-507471
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507471
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر