A Dataset of Experimental HLA-B*2705 Peptide Binding Affinities

الملخص EN

T-cell epitopes form the basis of many vaccines, diagnostics, and reagents.

Current methods for the in silico identification of T-cell epitopes rely, in the main, on the accurate quantitative prediction of peptide-Major Histocompatibility Complex (pMHC) affinity using data-driven computational approaches.

Here, we describe a dataset of experimentally determined pMHC binding affinities for the problematic human class I allele HLA-B*2705.

Using an in-house, FACS-based, MHC stabilization assay, we measured binding of 223 peptides.

This dataset includes both nonbinding and binding peptides, with measured affinities (expressed as −log10 of the half-maximal binding level) ranging from 1.2 to 7.4.

This dataset should provide a useful independent benchmark for new and existing methods for predicting peptide binding to HLA-B*2705.