Resection of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma : A Western Experience

المؤلفون المشاركون

Jibara, Ghalib A.
Roayaie, Sasan
Shrager, Brian
Ward, Stephen C.
Tabrizian, Parissa

المصدر

International Journal of Surgical Oncology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-09-04

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Introduction.

Hepatocellular carcinoma is now known to arise in association with nonalcoholic steatohepatitis.

The aim of this study is to examine the clinicopathological features of this entity using liver resection cases at a large Western center.

Methods.

We retrospectively reviewed all cases of partial liver resection for hepatocellular carcinoma over a 10-year period.

We included for the purpose of this study patients with histological evidence of nonalcoholic steatohepatitis and excluded patients with other chronic liver diseases such as viral hepatitis and alcoholic liver disease.

Results.

We identified 9 cases in which malignancy developed against a parenchymal background of histologically-active nonalcoholic steatohepatitis.

The median age at diagnosis was 58 (52–82) years, and 8 of the patients were male.

Median body mass index was 30.2 (22.7–39.4) kg/m2.

Hypertension was present in 77.8% of the patients and diabetes mellitus, obesity, and hyperlipidemia in 66.7%, respectively.

The background liver parenchyma was noncirrhotic in 44% of the cases.

Average tumor diameter was 7.0±4.8 cm.

Three-fourths of the patients developed recurrence within two years of resection, and 5-year survival was 44%.

Conclusion.

Hepatocellular carcinoma may arise in the context of nonalcoholic steatohepatitis, often before cirrhosis has developed.

Locally advanced tumors are typical, and long-term failure rate following resection is high.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Shrager, Brian& Jibara, Ghalib A.& Tabrizian, Parissa& Roayaie, Sasan& Ward, Stephen C.. 2012. Resection of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma : A Western Experience. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-507732

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Shrager, Brian…[et al.]. Resection of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma : A Western Experience. International Journal of Surgical Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-507732

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Shrager, Brian& Jibara, Ghalib A.& Tabrizian, Parissa& Roayaie, Sasan& Ward, Stephen C.. Resection of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma : A Western Experience. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-507732

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-507732