HPV Infection in a Cohort of HIV-Positive Men and Women : Prevalence of Oncogenic Genotypes and Predictors of Mucosal Damage at Genital and Oral Sites

الملخص EN

The aim of this study was to assess the prevalence of HPV infection and determinants of abnormal cytology in HIV-positive patients.

In a cross-sectional study, patients of both sexes, asymptomatic for HPV, underwent anorectal (men)/cervical (women) and oral swabs.

Cytology and HPV-PCR detection/genotyping (high- and low-risk genotypes, HR-LR/HPV) were performed.

A total of 20% of the 277 enrolled patients showed oral HPV, with no atypical cytology; in men, anal HPV prevalence was 81% with 64% HR genotypes.

In women, cervical HPV prevalence was 58% with 37% HR-HPV.

The most frequent genotypes were HPV-16 and HPV-18; 37% of men and 20% of women harbored multiple genotypes.

Also, 47% of men showed anal squamous intraepithelial lesions (SILs); 6% had high- and 35% low-grade SILs (HSILs/LSILs); 5% had atypical squamous cells of undetermined significance (ASC-US).

HR-HPV was independently associated with anal-SIL in men (P=0.039).

Moreover, 37% of women showed cervical SIL: 14 ASC-US, 15 LSILs, 4 HSILs, and 1 in situ cancer.

The presence of both LR and HR-HPV in women was independently associated with SIL (P=0.003 and P=0.0001).

HR-HPV and atypical cytology were frequently identified in our cohort.

HPV screening should be mandatory in HIV-infected subjects, and vaccine programs for HPV-negative patients should be implemented.