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Differential Macrophage Response to Slow- and Fast-Growing Pathogenic Mycobacteria
المؤلفون المشاركون
Ortiz-Navarrete, Vianney
Chacon-Salinas, Rommel
Cerna-Cortes, Jorge F.
Estrada-Garcia, Iris
Rivera-Gutierrez, Sandra
Gonzalez-y-Merchand, Jorge A.
Helguera-Repetto, A. Cecilia
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Nontuberculous mycobacteria (NTM) have recently been recognized as important species that cause disease even in immunocompetent individuals.
The mechanisms that these species use to infect and persist inside macrophages are not well characterised.
To gain insight concerning this process we used THP-1 macrophages infected with M.
abscessus, M.
fortuitum, M.
celatum, and M.
tuberculosis.
Our results showed that slow-growing mycobacteria gained entrance into these cells with more efficiency than fast-growing mycobacteria.
We have also demonstrated that viable slow-growing M.
celatum persisted inside macrophages without causing cell damage and without inducing reactive oxygen species (ROS), as M.
tuberculosis caused.
In contrast, fast-growing mycobacteria destroyed the cells and induced high levels of ROS.
Additionally, the macrophage cytokine pattern induced by M.
celatum was different from the one induced by either M.
tuberculosis or fast-growing mycobacteria.
Our results also suggest that, in some cases, the intracellular survival of mycobacteria and the immune response that they induce in macrophages could be related to their growth rate.
In addition, the modulation of macrophage cytokine production, caused by M.
celatum, might be a novel immune-evasion strategy used to survive inside macrophages that is different from the one reported for M.
tuberculosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Helguera-Repetto, A. Cecilia& Chacon-Salinas, Rommel& Cerna-Cortes, Jorge F.& Rivera-Gutierrez, Sandra& Ortiz-Navarrete, Vianney& Estrada-Garcia, Iris…[et al.]. 2014. Differential Macrophage Response to Slow- and Fast-Growing Pathogenic Mycobacteria. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-507870
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Helguera-Repetto, A. Cecilia…[et al.]. Differential Macrophage Response to Slow- and Fast-Growing Pathogenic Mycobacteria. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-507870
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Helguera-Repetto, A. Cecilia& Chacon-Salinas, Rommel& Cerna-Cortes, Jorge F.& Rivera-Gutierrez, Sandra& Ortiz-Navarrete, Vianney& Estrada-Garcia, Iris…[et al.]. Differential Macrophage Response to Slow- and Fast-Growing Pathogenic Mycobacteria. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-507870
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507870
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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