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Genomic Structure and Evolution of Multigene Families : “Flowers” on the Human Genome
المؤلفون المشاركون
Takahata, Naoyuki
Kim, Hie Lim
Kaneko, Satoko
Katsura, Yukako
Satta, Yoko
Igawa, Takeshi
Iwase, Mineyo
Nishioka, Tasuku
المصدر
International Journal of Evolutionary Biology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We report the results of an extensive investigation of genomic structures in the human genome, with a particular focus on relatively large repeats (>50 kb) in adjacent chromosomal regions.
We named such structures “Flowers” because the pattern observed on dot plots resembles a flower.
We detected a total of 291 Flowers in the human genome.
They were predominantly located in euchromatic regions.
Flowers are gene-rich compared to the average gene density of the genome.
Genes involved in systems receiving environmental information, such as immunity and detoxification, were overrepresented in Flowers.
Within a Flower, the mean number of duplication units was approximately four.
The maximum and minimum identities between homologs in a Flower showed different distributions; the maximum identity was often concentrated to 100% identity, while the minimum identity was evenly distributed in the range of 78% to 100%.
Using a gene conversion detection test, we found frequent and/or recent gene conversion events within the tested Flowers.
Interestingly, many of those converted regions contained protein-coding genes.
Computer simulation studies suggest that one role of such frequent gene conversions is the elongation of the life span of gene families in a Flower by the resurrection of pseudogenes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Hie Lim& Iwase, Mineyo& Igawa, Takeshi& Nishioka, Tasuku& Kaneko, Satoko& Katsura, Yukako…[et al.]. 2012. Genomic Structure and Evolution of Multigene Families : “Flowers” on the Human Genome. International Journal of Evolutionary Biology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-507984
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Hie Lim…[et al.]. Genomic Structure and Evolution of Multigene Families : “Flowers” on the Human Genome. International Journal of Evolutionary Biology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-507984
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Hie Lim& Iwase, Mineyo& Igawa, Takeshi& Nishioka, Tasuku& Kaneko, Satoko& Katsura, Yukako…[et al.]. Genomic Structure and Evolution of Multigene Families : “Flowers” on the Human Genome. International Journal of Evolutionary Biology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-507984
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-507984
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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