Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11
المؤلفون المشاركون
Fujita, Yukihisa
Akaho, Eiichi
Ali, Hamed I.
Yamada, Morio
Maeda, Mitsuko
المصدر
International Journal of Medicinal Chemistry
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-09-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We investigated the 16α-hydroxylation of steroid molecules and regioselective binding mode in homology-modeled cytochrome P450-2C11 to correlate the biological study with the computational molecular modeling.
It revealed that there was a positive relationship between the observed inhibitory potencies and the binding free energies.
Docking of steroid molecules into this homology-modeled CYP2C11 indicated that 16α-hydroxylation is favored with steroidal molecules possessing the following components, (1) a bent A-B ring configuration (5β-reduced), (2) C-3 α-hydroxyl group, (3) C-17β-acetyl group, and (4) methyl group at both the C-18 and C-19.
These respective steroid components requirements were defined as the inhibitory contribution factor.
Overall studies of the male rat CYP2C11 metabolism revealed that the above-mentioned steroid components requirements were essential to induce an effective inhibition of [3H]progesterone 16α-hydroxylation.
As far as docking of homology-modeled CYP2C11 against investigated steroids is concerned, they are docked at the active site superimposed with flurbiprofen.
It was also found that the distance between heme iron and C16α-H was between 4 to 6 Å and that the related angle was in the range of 180±45∘.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Hamed I.& Yamada, Morio& Fujita, Yukihisa& Maeda, Mitsuko& Akaho, Eiichi. 2010. Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11. International Journal of Medicinal Chemistry،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-508036
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Hamed I.…[et al.]. Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11. International Journal of Medicinal Chemistry No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-508036
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Hamed I.& Yamada, Morio& Fujita, Yukihisa& Maeda, Mitsuko& Akaho, Eiichi. Studies on 16α-Hydroxylation of Steroid Molecules and Regioselective Binding Mode in Homology-Modeled Cytochrome P450-2C11. International Journal of Medicinal Chemistry. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-508036
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508036
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر