Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats
المؤلفون المشاركون
Tian, Ying
Jin, Xingming
Shen, Xiaoming
Yan, Chonghuai
Li, Fei
Zhang, Yuanyuan
Cao, Xiaohua
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-01-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
To investigate the influence of forepaw sensorimotor deprivation on memory and synaptic plasticity, Sprague-Dawley rats were divided into two groups: a sham-operated group and a group deprived of forepaw sensorimotor function by microsurgical operation at postnatal day 13 (PN13).
Behavioral and electrophysiological studies were performed at PN25, PN35, PN45, and PN60.
Open field test was used to assess the spontaneous locomotor activity.
Morris water maze was used to evaluate spatial reference learning and memory.
The long-term potentiation (LTP) in the medial perforant path—dentate gyrus (MPP-DG) pathway was examined with hippocampal slices.
We found that forepaw sensorimotor deprivation did not affect spontaneous activity of the rats.
However, spatial reference learning and memory were significantly impaired in their early life (PN25, PN35, and PN45).
In accordance with the behavior results, LTP in MPP-DG pathway was significantly suppressed in their early life.
These data demonstrated that forepaw sensorimotor deprivation led to the impairments on spatial memory via inducing pronounced deficits in the MPP-DG pathway to exhibit LTP, one of the major cellular mechanisms underlying learning and memory.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yuanyuan& Li, Fei& Cao, Xiaohua& Jin, Xingming& Yan, Chonghuai& Tian, Ying…[et al.]. 2010. Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-508135
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yuanyuan…[et al.]. Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-508135
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yuanyuan& Li, Fei& Cao, Xiaohua& Jin, Xingming& Yan, Chonghuai& Tian, Ying…[et al.]. Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats. Journal of Biomedicine and Biotechnology. 2010. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-508135
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508135
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر