The Clinicopathological Significance of miR-133a in Colorectal Cancer
المؤلفون المشاركون
Ng, Lui
Chow, Ariel Ka-Man
Poon, Ronnie Tung-Ping
Foo, Dominic
Wan, Timothy Ming-Hun
Lam, Colin Siu-Chi
Wong, Sunny Kit-Man
Lo, Oswens Siu-Hung
Cheung, Alvin
Man, Johnny Hon-Wai
Li, Hung-Sing
Pang, Roberta Wen-Chi
Poon, Jensen Tung-Chung
Law, Wai-Lun
Yau, Thomas
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study determined the expression of microRNA-133a (MiR-133a) in colorectal cancer (CRC) and adjacent normal mucosa samples and evaluated its clinicopathological role in CRC.
The expression of miR-133a in 125 pairs of tissue samples was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and correlated with patient’s clinicopathological data by statistical analysis.
Endogenous expression levels of several potential target genes were determined by qRT-PCR and correlated using Pearson’s method.
MiR-133a was downregulated in 83.2% of tumors compared to normal mucosal tissue.
Higher miR-133a expression in tumor tissues was associated with development of distant metastasis, advanced Dukes and TNM staging, and poor survival.
The unfavorable prognosis of higher miR-133a expression was accompanied by dysregulation of potential miR-133a target genes, LIM and SH3 domain protein 1 (LASP1), Caveolin-1 (CAV1), and Fascin-1 (FSCN1).
LASP1 was found to possess a negative correlation (γ=-0.23), whereas CAV1 exhibited a significant positive correlation (γ=0.27), and a stronger correlation was found in patients who developed distant metastases (γ=0.42).
In addition, a negative correlation of FSCN1 was only found in nonmetastatic patients.
In conclusion, miR-133a was downregulated in CRC tissues, but its higher expression correlated with adverse clinical characteristics and poor prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wan, Timothy Ming-Hun& Lam, Colin Siu-Chi& Ng, Lui& Chow, Ariel Ka-Man& Wong, Sunny Kit-Man& Li, Hung-Sing…[et al.]. 2014. The Clinicopathological Significance of miR-133a in Colorectal Cancer. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-508137
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wan, Timothy Ming-Hun…[et al.]. The Clinicopathological Significance of miR-133a in Colorectal Cancer. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-508137
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wan, Timothy Ming-Hun& Lam, Colin Siu-Chi& Ng, Lui& Chow, Ariel Ka-Man& Wong, Sunny Kit-Man& Li, Hung-Sing…[et al.]. The Clinicopathological Significance of miR-133a in Colorectal Cancer. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-508137
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508137
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر