Protein Oxidative Damage at the Crossroads of Cellular Senescence, Aging, and Age-Related Diseases
المؤلفون المشاركون
Liu, Liang
Friguet, Bertrand
Ahmed, Emad K.
Baraibar, Martin A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Protein damage mediated by oxidation, protein adducts formation with advanced glycated end products and with products of lipid peroxidation, has been implicated during aging and age-related diseases, such as neurodegenerative diseases.
Increased protein modification has also been described upon replicative senescence of human fibroblasts, a valid model for studying aging in vitro.
However, the mechanisms by which these modified proteins could impact on the development of the senescent phenotype and the pathogenesis of age-related diseases remain elusive.
In this study, we performed in silico approaches to evidence molecular actors and cellular pathways affected by these damaged proteins.
A database of proteins modified by carbonylation, glycation, and lipid peroxidation products during aging and age-related diseases was built and compared to those proteins identified during cellular replicative senescence in vitro.
Common cellular pathways evidenced by enzymes involved in intermediate metabolism were found to be targeted by these modifications, although different tissues have been examined.
These results underscore the potential effect of protein modification in the impairment of cellular metabolism during aging and age-related diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baraibar, Martin A.& Liu, Liang& Ahmed, Emad K.& Friguet, Bertrand. 2012. Protein Oxidative Damage at the Crossroads of Cellular Senescence, Aging, and Age-Related Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baraibar, Martin A.…[et al.]. Protein Oxidative Damage at the Crossroads of Cellular Senescence, Aging, and Age-Related Diseases. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-508172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baraibar, Martin A.& Liu, Liang& Ahmed, Emad K.& Friguet, Bertrand. Protein Oxidative Damage at the Crossroads of Cellular Senescence, Aging, and Age-Related Diseases. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-508172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر