Quantitative Proteomics Analysis by Isobaric Tags for Relative and Absolute Quantitation Identified Lumican as a Potential Marker for Acute Aortic Dissection
المؤلفون المشاركون
Yin, Jun
Rao, Andrew
Rao, Jianyu
Yao, Chenling
Ku, Matthew
Cheng, Weizhong
Yen, Lawrence
Tong, Chaoyang
Gu, Guorong
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Acute aortic dissection (AAD) is a serious vascular disease.
Currently the diagnosis relies on clinical and radiological means whereas serum biomarkers are lacking.
The purpose of this study was to identify potential serum biomarkers for AAD using isobaric tags for relative and absolute quantitation (iTRAQ) approach.
A total of 120 serum samples were collected from three groups: AAD patients (n=60), patients with acute myocardial infarction (AMI, n=30), and healthy volunteers (n=30), whereas the first 10 samples from each group were used for iTRAQ analysis.
Using iTRAQ approach, a total of 174 proteins were identified as significantly different between AAD patients and healthy subjects.
Among them, forty-six proteins increased more than twofold, full-scale analysis using serum sample for the entire 120 subjects demonstrated that Lumican level was significantly increased relative to control and AMI samples.
Further, Lumican level correlated with time from onset to admission in AAD but not AMI samples.
Using iTRAQ approach, our study showed that Lumican may be a potential AAD-related serum marker that may assist the diagnosis of AAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gu, Guorong& Cheng, Weizhong& Yao, Chenling& Yin, Jun& Tong, Chaoyang& Rao, Andrew…[et al.]. 2011. Quantitative Proteomics Analysis by Isobaric Tags for Relative and Absolute Quantitation Identified Lumican as a Potential Marker for Acute Aortic Dissection. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-508255
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gu, Guorong…[et al.]. Quantitative Proteomics Analysis by Isobaric Tags for Relative and Absolute Quantitation Identified Lumican as a Potential Marker for Acute Aortic Dissection. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-508255
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gu, Guorong& Cheng, Weizhong& Yao, Chenling& Yin, Jun& Tong, Chaoyang& Rao, Andrew…[et al.]. Quantitative Proteomics Analysis by Isobaric Tags for Relative and Absolute Quantitation Identified Lumican as a Potential Marker for Acute Aortic Dissection. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-508255
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508255
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر