Topography Prediction of Helical Transmembrane Proteins by a New Modification of the Sliding Window Method
المؤلفون المشاركون
Simakov, Nikolai N.
Simakova, Maria N.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Protein functions are specified by its three-dimensional structure, which is usually obtained by X-ray crystallography.
Due to difficulty of handling membrane proteins experimentally to date the structure has only been determined for a very limited part of membrane proteins (<4%).
Nevertheless, investigation of structure and functions of membrane proteins is important for medicine and pharmacology and, therefore, is of significant interest.
Methods of computer modeling based on the data on the primary protein structure or the symbolic amino acid sequence have become an actual alternative to the experimental method of X-ray crystallography for investigating the structure of membrane proteins.
Here we presented the results of the study of 35 transmembrane proteins, mainly GPCRs, using the novel method of cascade averaging of hydrophobicity function within the limits of a sliding window.
The proposed method allowed revealing 139 transmembrane domains out of 140 (or 99.3%) identified by other methods.
Also 236 transmembrane domain boundary positions out of 280 (or 84%) were predicted correctly by the proposed method with deviation from the predictions made by other methods that does not exceed the detection error of this method.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Simakova, Maria N.& Simakov, Nikolai N.. 2014. Topography Prediction of Helical Transmembrane Proteins by a New Modification of the Sliding Window Method. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-508290
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Simakova, Maria N.& Simakov, Nikolai N.. Topography Prediction of Helical Transmembrane Proteins by a New Modification of the Sliding Window Method. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-508290
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Simakova, Maria N.& Simakov, Nikolai N.. Topography Prediction of Helical Transmembrane Proteins by a New Modification of the Sliding Window Method. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-508290
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508290
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر