Gene Expression Analysis of an EGFR Indirectly Related Pathway Identified PTEN and MMP9 as Reliable Diagnostic Markers for Human Glial Tumor Specimens
المؤلفون المشاركون
Sbalchiero, Elena
Paolillo, Mayra
Comincini, Sergio
Barbieri, Giulia
Schinelli, Sergio
Palumbo, Silvia
Azzalin, Alberto
Russo, Marika A.
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-07-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In this study the mRNA levels of five EGFR indirectly related genes, EGFR, HB-EGF, ADAM17, PTEN, and MMP9, have been assessed by Real-time PCR in a panel of 37 glioblastoma multiforme specimens and in 5 normal brain samples; as a result, in glioblastoma, ADAM17 and PTEN expression was significantly lower than in normal brain samples, and, in particular, a statistically significant inverse correlation was found between PTEN and MMP9 mRNA levels.
To verify if this correlation was conserved in gliomas, PTEN and MMP9 expression was further investigated in an additional panel of 16 anaplastic astrocytoma specimens and, in parallel, in different human normal and astrocytic tumor cell lines.
In anaplastic astrocytomas PTEN expression was significantly higher than in glioblastoma multiforme, but no significant correlation was found between PTEN and MMP9 expression.
PTEN and MMP9 mRNA levels were also employed to identify subgroups of specimens within the different glioma malignancy grades and to define a gene expression-based diagnostic classification scheme.
In conclusion, this gene expression survey highlighted that the combined measurement of PTEN and MMP9 transcripts might represent a novel reliable tool for the differential diagnosis of high-grade gliomas, and it also suggested a functional link involving these genes in glial tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Comincini, Sergio& Paolillo, Mayra& Barbieri, Giulia& Palumbo, Silvia& Sbalchiero, Elena& Azzalin, Alberto…[et al.]. 2009. Gene Expression Analysis of an EGFR Indirectly Related Pathway Identified PTEN and MMP9 as Reliable Diagnostic Markers for Human Glial Tumor Specimens. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-508503
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Comincini, Sergio…[et al.]. Gene Expression Analysis of an EGFR Indirectly Related Pathway Identified PTEN and MMP9 as Reliable Diagnostic Markers for Human Glial Tumor Specimens. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-508503
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Comincini, Sergio& Paolillo, Mayra& Barbieri, Giulia& Palumbo, Silvia& Sbalchiero, Elena& Azzalin, Alberto…[et al.]. Gene Expression Analysis of an EGFR Indirectly Related Pathway Identified PTEN and MMP9 as Reliable Diagnostic Markers for Human Glial Tumor Specimens. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-508503
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508503
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر