Amelanotic Melanoma Masquerading as a Granular Cell Lesion

الملخص EN

Amelanotic melanoma (AM) presents a diagnostic challenge due to its wide clinical presentations, lack of pigmentation, and varied histological appearances.

Immunohistochemistry plays a crucial role in the diagnosis of these lesions.

Amelanotic melanoma of oral mucosa is an uncommon lesion.

We report a case of a 50-year-old male patient with a growth on the anterior mandibular gingiva of seven-month duration.

In the present case, histologically, the tumour resembled a granular cell lesion, which has not been reported previously in AM.

Diagnosis was possible by a sequential panel of immunohistochemical markers, of which finally vimentin, S100, HMB45, and Melan-A were positive.

The tumor was surgically excised, and postsurgical radiotherapy was given.