Gradually Increased Training Intensity Benefits Rehabilitation Outcome after Stroke by BDNF Upregulation and Stress Suppression
المؤلفون المشاركون
Sun, Jing
Yip, Shea Ping
Ke, Zheng
Zheng, Xiao-xiang
Hu, Xiao-ling
Tong, Kai-yu
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Physical training is necessary for effective rehabilitation in the early poststroke period.
Animal studies commonly use fixed training intensity throughout rehabilitation and without adapting it to the animals' recovered motor ability.
This study investigated the correlation between training intensity and rehabilitation efficacy by using a focal ischemic stroke rat model.
Eighty male Sprague-Dawley rats were induced with middle cerebral artery occlusion/reperfusion surgery.
Sixty rats with successful stroke were then randomly assigned into four groups: control (CG, n=15), low intensity (LG, n=15), gradually increased intensity (GIG, n=15), and high intensity (HG, n=15).
Behavioral tests were conducted daily to evaluate motor function recovery.
Stress level and neural recovery were evaluated via plasma corticosterone and brain-derived neurotrophic factor (BDNF) concentration, respectively.
GIG rats significantly (P<0.05) recovered motor function and produced higher hippocampal BDNF (112.87 ± 25.18 ng/g).
GIG and LG rats exhibited similar stress levels (540.63 ± 117.40 nM/L and 508.07 ± 161.30 nM/L, resp.), which were significantly lower (P<0.05) than that (716.90 ± 156.48 nM/L) of HG rats.
Training with gradually increased intensity achieved better recovery with lower stress.
Our observations indicate that a training protocol that includes gradually increasing training intensity should be considered in both animal and clinical studies for better stroke recovery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Jing& Ke, Zheng& Yip, Shea Ping& Hu, Xiao-ling& Zheng, Xiao-xiang& Tong, Kai-yu. 2014. Gradually Increased Training Intensity Benefits Rehabilitation Outcome after Stroke by BDNF Upregulation and Stress Suppression. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-508619
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Jing…[et al.]. Gradually Increased Training Intensity Benefits Rehabilitation Outcome after Stroke by BDNF Upregulation and Stress Suppression. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-508619
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Jing& Ke, Zheng& Yip, Shea Ping& Hu, Xiao-ling& Zheng, Xiao-xiang& Tong, Kai-yu. Gradually Increased Training Intensity Benefits Rehabilitation Outcome after Stroke by BDNF Upregulation and Stress Suppression. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-508619
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508619
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر