LPS-Induced Inflammation Potentiates the IL-1β-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants

المؤلفون المشاركون

Dobek, Elżbieta
Herman, Anna
Herman, Andrzej Przemysław
Krawczyńska, Agata
Bochenek, Joanna
Tomaszewska-Zaremba, Dorota

المصدر

Clinical and Developmental Immunology

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-07-17

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الملخص EN

Acting at the level of the brain, interleukin- (IL-)1β is considered to be one of the most potent downregulators of reproduction processes during immune/inflammatory challenge.

IL-1β suppresses gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus resulting in the inhibition of the luteinizing hormone (LH) release from the anterior pituitary (AP).

However, the presence of IL-1β receptors in the AP suggests the possible direct action of this cytokine on LH secretion.

The study was designed to determine the effect of IL-1β on the LH secretion from the AP explants collected from saline and LPS-treated ewes in the follicular phase.

It was found that IL-1β suppressed (P≤0.01) GnRH-stimulated LH release and LHβ gene expression in AP explants in both groups.

However, IL-1β action was more potent in the explants collected from LPS-treated animals.

Pituitaries from LPS-treated animals were characterized by increased (P≤0.01) IL-1 type I receptor and decreased (P≤0.01) GnRH receptor gene expression level compared to the saline-treated group.

IL-1β also affected the GnRH-R gene expression in explants collected from LPS-treated animals.

Our results show that direct action of IL-1β on the pituitary gonadotropes could be one of the reasons of the reproductive processes disorders accompanying an inflammatory state.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Herman, Andrzej Przemysław& Krawczyńska, Agata& Bochenek, Joanna& Dobek, Elżbieta& Herman, Anna& Tomaszewska-Zaremba, Dorota. 2013. LPS-Induced Inflammation Potentiates the IL-1β-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-508740

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Herman, Andrzej Przemysław…[et al.]. LPS-Induced Inflammation Potentiates the IL-1β-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-508740

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Herman, Andrzej Przemysław& Krawczyńska, Agata& Bochenek, Joanna& Dobek, Elżbieta& Herman, Anna& Tomaszewska-Zaremba, Dorota. LPS-Induced Inflammation Potentiates the IL-1β-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-508740

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-508740