Effect of Clonidine (an Antihypertensive Drug) Treatment on Oxidative Stress Markers in the Heart of Spontaneously Hypertensive Rats
المؤلفون المشاركون
Mustapha, Zulkarnain
Nik Yusoff, Nik Syamimi
Govindasamy, Chandran
Sirajudeen, K. N. S.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Hypertension is a risk factor for several cardiovascular diseases and oxidative stress suggested to be involved in the pathophysiology.
Antihypertensive drug Clonidine action in ameliorating oxidative stress was not well studied.
Therefore, this study investigate the effect of Clonidine on oxidative stress markers and nitric oxide (NO) in SHR and nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME) administered SHR.
Male rats were divided into four groups [SHR, SHR+Clonidine (SHR-C), SHR+L-NAME, SHR+Clonidine+L-NAME(SHRC+L-NAME)].
Rats (SHRC) were administered with Clonidine (0.5 mg kg−1 day−1) from 4 weeks to 28 weeks in drinking water and L-NAME (25 mg kg−1 day−1) from 16 weeks to 28 weeks to SHRC+L-NAME.
Systolic blood pressure (SBP) was measured.
At the end of 28 weeks, all rats were sacrificed and in their heart homogenate, oxidative stress parameters and NO was assessed.
Clonidine treatment significantly enhanced the total antioxidant status (TAS) (P<0.001) and reduced the thibarbituric acid reactive substances (TBARS) (P<0.001) and protein carbonyl content (PCO) (P<0.05).
These data suggest that oxidative stress is involved in the hypertensive organ damage and Clonidine not only lowers the SBP but also ameliorated the oxidative stress in the heart of SHR and SHR+L-NAME.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nik Yusoff, Nik Syamimi& Mustapha, Zulkarnain& Govindasamy, Chandran& Sirajudeen, K. N. S.. 2013. Effect of Clonidine (an Antihypertensive Drug) Treatment on Oxidative Stress Markers in the Heart of Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-508755
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nik Yusoff, Nik Syamimi…[et al.]. Effect of Clonidine (an Antihypertensive Drug) Treatment on Oxidative Stress Markers in the Heart of Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-508755
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nik Yusoff, Nik Syamimi& Mustapha, Zulkarnain& Govindasamy, Chandran& Sirajudeen, K. N. S.. Effect of Clonidine (an Antihypertensive Drug) Treatment on Oxidative Stress Markers in the Heart of Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-508755
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508755
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر