Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation
المؤلفون المشاركون
Moccetti, Tiziano
Milano, Giuseppina
Vassalli, Giuseppe
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-18
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
In solid organ transplantation, ischemia/reperfusion (IR) injury during organ procurement, storage and reperfusion is an unavoidable detrimental event for the graft, as it amplifies graft inflammation and rejection.
Intracellular mitogen-activated protein kinase (MAPK) signaling pathways regulate inflammation and cell survival during IR injury.
The four best-characterized MAPK subfamilies are the c-Jun NH2-terminal kinase (JNK), extracellular signal- regulated kinase-1/2 (ERK1/2), p38 MAPK, and big MAPK-1 (BMK1/ERK5).
Here, we review the role of MAPK activation during myocardial IR injury as it occurs during heart transplantation.
Most of our current knowledge regarding MAPK activation and cardioprotection comes from studies of preconditioning and postconditioning in nontransplanted hearts.
JNK and p38 MAPK activation contributes to myocardial IR injury after prolonged hypothermic storage.
p38 MAPK inhibition improves cardiac function after cold storage, rewarming and reperfusion.
Small-molecule p38 MAPK inhibitors have been tested clinically in patients with chronic inflammatory diseases, but not in transplanted patients, so far.
Organ transplantation offers the opportunity of starting a preconditioning treatment before organ procurement or during cold storage, thus modulating early events in IR injury.
Future studies will need to evaluate combined strategies including p38 MAPK and/or JNK inhibition, ERK1/2 activation, pre- or postconditioning protocols, new storage solutions, and gentle reperfusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vassalli, Giuseppe& Milano, Giuseppina& Moccetti, Tiziano. 2012. Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-508936
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vassalli, Giuseppe…[et al.]. Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation. Journal of Transplantation No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-508936
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vassalli, Giuseppe& Milano, Giuseppina& Moccetti, Tiziano. Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-508936
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-508936
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر