![](/images/graphics-bg.png)
The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population : The Genetics of Atherosclerotic Disease Mexican Study
المؤلفون المشاركون
Vargas-Alarcón, Gilberto
Alvarez-León, Edith
Soto, María Elena
Ramirez-Bello, Julian
Juárez, Juan Gabriel
Rodríguez-Pérez, José Manuel
Angeles-Martinez, Javier
Monroy-Muñoz, Irma
Ramírez-Fuentes, Silvestre
Sánchez-Ramírez, Carlos Jerges
Villarreal-Molina, Teresa
Posadas-Romero, Carlos
Fragoso, José Manuel
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Coronary artery disease (CAD) is a multifactorial disorder that results from an excessive inflammatory response.
Secretory phospholipase A2-V (sPLA2-V) encoded by PLA2G5 gene promotes diverse proinflammatory processes.
The aim of the present study was to analyze if PLA2G5 gene polymorphisms are associated with premature CAD.
Three PLA2G5 polymorphisms (rs11573187, rs2148911, and rs11573191) were analyzed in 707 patients with premature CAD and 749 healthy controls.
Haplotypes were constructed after linkage disequilibrium analysis.
Under dominant, recessive, and additive models, the rs11573191 polymorphism was associated with increased risk of premature CAD (OR = 1.51, Pdom = 3.5 × 10−3; OR = 2.95, Prec = 0.023; OR = 1.51, Padd = 1.2 × 10−3).
According to the informatics software, this polymorphism had a functional effect modifying the affinity of the sequence by the MZF1 transcription factor.
PLA2G5 polymorphisms were in linkage disequilibrium and the CGA haplotype was associated with increased risk of premature CAD (OR = 1.49, P = 0.0023) and with hypertension in these patients (OR = 1.75, P = 0.0072).
Our results demonstrate the association of the PLA2G5 rs11573191 polymorphism with premature CAD.
In our study, it was possible to distinguish one haplotype associated with increased risk of premature CAD and hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vargas-Alarcón, Gilberto& Posadas-Romero, Carlos& Villarreal-Molina, Teresa& Alvarez-León, Edith& Angeles-Martinez, Javier& Soto, María Elena…[et al.]. 2014. The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population : The Genetics of Atherosclerotic Disease Mexican Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-509151
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vargas-Alarcón, Gilberto…[et al.]. The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population : The Genetics of Atherosclerotic Disease Mexican Study. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-509151
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vargas-Alarcón, Gilberto& Posadas-Romero, Carlos& Villarreal-Molina, Teresa& Alvarez-León, Edith& Angeles-Martinez, Javier& Soto, María Elena…[et al.]. The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population : The Genetics of Atherosclerotic Disease Mexican Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-509151
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509151
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)