Improved Convenient Synthesis of Benzoyl Metronidazole : A Nitroimidazole Antibiotics

الملخص EN

An improved, cost-effective, and one-pot method for the synthesis of benzoyl metronidazole was achieved by using N,N′-carbonyldiimidazole as a coupling reagent.

Moreover, the byproduct imidazole as the catalyst promoted the reaction.

The procedures are simple and suitable to large-scale manufactures.