Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals

المؤلفون المشاركون

Khalid, Syamimi
Lajis, Nordin
Shaik Mossadeq, Wan Mastura
Israf, Daud
Ahmad, Syahida
Mohd Padzil, Azyyati
Mohamad, Azam Shah
Sulaiman, Mohd Roslan
Shaari, Khozirah
Akira, Ahmad

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-01-02

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Melicope ptelefolia is a medicinal herb commonly used in Malaysia to treat fever, pain, wounds, and itches.

The present study was conducted to evaluate the antinociceptive activity of the Melicope ptelefolia ethanolic extract (MPEE) using animal models of nociception.

The antinociceptive activity of the extract was assessed using acetic acid-induced abdominal writhing, hot-plate, and formalin-induced paw licking tests.

Oral administration of MPEE produced significant dose-dependent antinociceptive effects when tested in mice and rats using acetic acid-induced abdominal constriction test and on the second phase of the formalin-induced paw licking test, respectively.

It was also demonstrated that MPEE had no effect on the response latency time to the heat stimulus in the thermal model of the hot-plate test.

In addition, the antinociception produced by MPEE was not blocked by naloxone.

Furthermore, oral administration of MPEE did not produce any effect in motor performance of the rota-rod test and in acute toxicity study no abnormal behaviors as well as mortality were observed up to a dose level of the extract of 5 g/kg.

These results indicated that MPEE at all doses investigated which did not produce any sedative and toxic effects exerted pronounce antinociceptive activity that acts peripherally in experimental animals.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Sulaiman, Mohd Roslan& Mohd Padzil, Azyyati& Shaari, Khozirah& Khalid, Syamimi& Shaik Mossadeq, Wan Mastura& Mohamad, Azam Shah…[et al.]. 2011. Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-509686

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Sulaiman, Mohd Roslan…[et al.]. Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-509686

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Sulaiman, Mohd Roslan& Mohd Padzil, Azyyati& Shaari, Khozirah& Khalid, Syamimi& Shaik Mossadeq, Wan Mastura& Mohamad, Azam Shah…[et al.]. Antinociceptive Activity of Melicope ptelefolia Ethanolic Extract in Experimental Animals. Journal of Biomedicine and Biotechnology. 2011. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-509686

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-509686