Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic HgWhole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population
المؤلفون المشاركون
de Oliveira, Andréia Ávila Soares
Cólus, Ilce Mara de Syllos
Braga, Gilberto Úbida Leite
de Oliveira, Marcelo Tempesta
Barcelos, Gustavo Rafael Mazzaron
Camargo, Rossana Batista de Oliveira Godoy
Lengert, André van Helvoort
Souza, Marilesia Ferreira de
Barbosa Junior, Fernando
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes (GSTM1, GSTT1, GSTP1, GCLM, and GCLC) in the distribution of Hg in the blood compartments in humans exposed to methylmercury (MeHg).
Subjects (n=88), exposed to MeHg from fish consumption, were enrolled in the study.
Hg species in the plasma compartment were determined by LC-ICP-MS, whereas genotyping was performed by PCR assays.
Mean total Hg levels in plasma (THgP) and whole blood (THgB) were 10±4.2 and 37±21, whereas mean evels of plasmatic MeHg (MeHgP), inorganic Hg (IHgP), and HgP/HgB were 4.3±2.9, 5.8±2.3 µg/L, and 0.33±0.15, respectively.
GSTM1 and GCLC polymorphisms influence THgP and MeHgP (multivariate analyses, P<0.050).
Null homozygotes for GSTM1 showed higher THgP and MeHgP levels compared to subjects with GSTM1 (THgP β=0.22, P=0.035; MeHgP β=0.30, P=0.050) and persons carrying at least one T allele for GCLC had significant higher MeHgP (β=0.59, P=0.046).
Also, polymorphic GCLM subjects had lower THgP/THgB than those with the nonvariant genotype.
Taken together, data of this study suggest that GSH-related polymorphisms may change the metabolism of MeHg by modifying the distribution of mercury species iin plasma compartment and the HgP/HgB partitioning.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Oliveira, Andréia Ávila Soares& Souza, Marilesia Ferreira de& Lengert, André van Helvoort& de Oliveira, Marcelo Tempesta& Camargo, Rossana Batista de Oliveira Godoy& Braga, Gilberto Úbida Leite…[et al.]. 2014. Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic HgWhole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-509964
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Oliveira, Andréia Ávila Soares…[et al.]. Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic HgWhole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-509964
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Oliveira, Andréia Ávila Soares& Souza, Marilesia Ferreira de& Lengert, André van Helvoort& de Oliveira, Marcelo Tempesta& Camargo, Rossana Batista de Oliveira Godoy& Braga, Gilberto Úbida Leite…[et al.]. Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic HgWhole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-509964
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-509964
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر