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Atherosclerosis Induced by Chlamydophila pneumoniae : A Controversial Theory
المؤلف
المصدر
Interdisciplinary Perspectives on Infectious Diseases
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
More than a century ago, inflammation and infection were considered to have atherogenic effects.
The old idea that coronary heart disease (CHD) possibly has an infectious etiology has only reemerged in recent years.
Atherosclerosis is the main pathological process involved in CHD and is, logically, the first place to look for infectious etiology.
The process of atherosclerosis itself provides the first hints of potential infectious cause.
Smooth muscle proliferation, with subsequent intimal thickening, luminal narrowing, and endothelial degeneration, constitutes the natural history of atherosclerosis, being with the severity and speed of these changes.
Both viral and bacterial pathogens have been proposed to be associated with the inflammatory changes found in atherosclerosis.
Recently, Chlamydophila pneumoniae (C.
pneumoniae) has been implicated as a possible etiologic agent of coronary artery disease and atherosclerosis.
New evidence which supports a role for C.
pneumoniae in the pathogenesis of atherosclerosis has emerged.
C.
pneumoniae has been detected in atherosclerotic arteries by several techniques, and the organism has been isolated from both coronary and carotid atheromas.
Recent animal models have suggested that C.
pneumoniae is capable of inducing atherosclerosis in both rabbit and mouse models of atherosclerosis.
Furthermore, human clinical treatment studies which examined the use of antichlamydial macrolide antibiotics in patients with coronary atherosclerosis have been carried out.
The causal relationship has not yet been proven, but ongoing large intervention trials and research on pathogenetic mechanisms may lead to the use of antimicrobial agents in the treatment of CHD in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Honarmand, Hamidreza. 2013. Atherosclerosis Induced by Chlamydophila pneumoniae : A Controversial Theory. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-510004
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Honarmand, Hamidreza. Atherosclerosis Induced by Chlamydophila pneumoniae : A Controversial Theory. Interdisciplinary Perspectives on Infectious Diseases No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-510004
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Honarmand, Hamidreza. Atherosclerosis Induced by Chlamydophila pneumoniae : A Controversial Theory. Interdisciplinary Perspectives on Infectious Diseases. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-510004
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510004
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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