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Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS
المؤلفون المشاركون
Cassuto-Viguier, E.
Parasuraman, Ravi
Peddi, V. Ram
Chan, Laurence
Hart, Marquis
Bunnapradist, Suphamai
Gugliuzza, Kristene
Andres, Amado
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Information is lacking concerning concomitant administration of enteric-coated mycophenolate sodium with tacrolimus (EC-MPS+Tac) in renal transplant recipients (RTxR).
In this 6-month, prospective, open-label, multicenter study, de novo RTxR were randomized (1 : 1) to low-dose (LD) or standard-dose (SD) Tac with basiliximab, EC-MPS 720 mg bid, and steroids.
Primary objective was to compare renal function at 6-month posttransplantation.
Secondary objectives were to compare the incidences of biopsy-proven acute rejection (BPAR), graft loss and death, and new-onset diabetes mellitus (NODM).
292 patients (LD n=151, SD n=141) were included.
Mean Tac levels were at the low end of the target range in standard-exposure patients (SD, n=141) and exceeded target range in low-exposure patients (LD = 151) throughout the study.
There was no significant difference in mean glomerular filtration rate (GFR) between treatments (ITT-population: 63.6 versus 61.0 mL/min).
Incidence of BPAR was similar (10.6% versus 9.9%).
NODM was significantly less frequent in LD Tac (17% versus 31%; P=0.02); other adverse effects (AEs) were comparable.
EC-MPS+Tac (LD/SD) was efficacious and well tolerated with well-preserved renal function.
No renal function benefits were demonstrated, possibly related to poor adherence to reduced Tac exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chan, Laurence& Andres, Amado& Bunnapradist, Suphamai& Gugliuzza, Kristene& Parasuraman, Ravi& Peddi, V. Ram…[et al.]. 2012. Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-510031
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chan, Laurence…[et al.]. Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS. Journal of Transplantation No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-510031
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chan, Laurence& Andres, Amado& Bunnapradist, Suphamai& Gugliuzza, Kristene& Parasuraman, Ravi& Peddi, V. Ram…[et al.]. Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-510031
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510031
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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