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MammaPrint Feasibility in a Large Tertiary Urban Medical Center : An Initial Experience
المؤلفون المشاركون
Taback, Bret
Keating, Shaughn
Feldman, Sheldon Marc
Espinel, C. Francisco
Hibshoosh, Hanina
Joseph, Kathie-Ann
El-Tamer, Mahmoud B.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأمراض
الملخص EN
Background.
The MammaPrint (MP) diagnostic assay stratifies breast cancer patients into high- and low-risk groups using mRNA analysis of a 70-gene profile.
The assay is validated for assessment of patients with estrogen receptor positive or negative tumors less than 5 cm with 3 or fewer malignant lymph nodes.
TargetPrint (TP) is an assay for assessing estrogen, progesterone, and HER2-neu receptor status based on mRNA expression.
A potential limitation of these assays is that they require an evaluation of fresh tissue samples.
There is limited published experience describing MP or TP implementation.
Methods.
Over 10 months, 4 breast surgeons obtained samples from 54 patients for MP/TP analysis.
The samples were analyzed by Agendia Labs.
The tumors were independently evaluated for receptor status using immunohistochemistry (IHC).
Retrospectively, we identified patients who were assessed by MP/TP during this period.
Patients who underwent OncotypeDx evaluation were also identified.
Results.
Of the 54 patients receiving MP, 4 were found ineligible for MP risk assessment because >3 lymph nodes were found to be malignant.
Out of all eligible patients, 14/50 (28%) had samples whose quantity of tumor was not sufficient for analysis (QNS).
Out of eligible patients with tumors <1 cm, 7/8 (88%) had QNS samples.
7/42 with tumors ≥1 cm (17%) had QNS samples.
Nine patients had discordant receptor results when evaluated by IHC versus.
TP.
Of patients who also underwent OncotypeDx testing, 6/14 (43%) had discordant results with MP.
Conclusions.
This study indicates that using MP/TP assay is feasible in a tertiary care center but there may be utility in limiting MP testing to patients with tumors between 1 and 5 cm due to high likelihood of uninformative results in subcentimeter tumors.
Further study is needed to explore the discordance between oncotype and MP results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Espinel, C. Francisco& Keating, Shaughn& Hibshoosh, Hanina& Taback, Bret& Joseph, Kathie-Ann& El-Tamer, Mahmoud B.…[et al.]. 2012. MammaPrint Feasibility in a Large Tertiary Urban Medical Center : An Initial Experience. Scientifica،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510122
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Espinel, C. Francisco…[et al.]. MammaPrint Feasibility in a Large Tertiary Urban Medical Center : An Initial Experience. Scientifica No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-510122
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Espinel, C. Francisco& Keating, Shaughn& Hibshoosh, Hanina& Taback, Bret& Joseph, Kathie-Ann& El-Tamer, Mahmoud B.…[et al.]. MammaPrint Feasibility in a Large Tertiary Urban Medical Center : An Initial Experience. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-510122
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510122
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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