Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats
المؤلفون المشاركون
Singh, Varun
Gullaiya, Sumeet
Nagar, Ashish
Kumar, Ashok
Agrawal, Shyam Sunder
Tiwari, Poonam
Dubey, Vishal
المصدر
Cardiovascular Psychiatry and Neurology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Study was undertaken to evaluate the neurodegenerative defending potential of curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) on 6-hydroxydopamine-(6-OHDA) induced Parkinsonism model in rats.
Curcuminoids were administered (60 mg/kg, body weight, per oral) for three weeks followed by unilateral injection of 6-OHDA on 22nd day (10 μg/2 μL) into the right striatum leading to extensive loss of dopaminergic cells.
The behavioral observations, biochemical markers, quantification of dopamine (DA), DOPAC, and HVA followed by dopamine (D2) receptor binding assay and tyrosine hydroxylase (TH, using immunohistochemistry) were evaluated using HPLC after three weeks of lesion.
Pretreated animals showed significant protection against neuronal degeneration compared to lesion animals by normalizing the deranged levels of biomarkers and showed the potency in the order CUR > DMC > BDMC.
The same order of effectiveness was observed in D2 receptors binding assay and TH immunohistochemistry study.
We conclude that curcuminoids appear to shield progressive neuronal degeneration from increased oxidative attack in 6-OHDA-lesioned rats through its free radical scavenging mechanism, and DA, DOPAC, and HVA enhancing capabilities in the sequence of efficacy CUR > DMC > BDMC.
Further, curcuminoids may have potential utility in treatment of many more oxidative stress-induced neurodegenerative disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Agrawal, Shyam Sunder& Gullaiya, Sumeet& Dubey, Vishal& Singh, Varun& Kumar, Ashok& Nagar, Ashish…[et al.]. 2012. Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats. Cardiovascular Psychiatry and Neurology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510164
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Agrawal, Shyam Sunder…[et al.]. Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats. Cardiovascular Psychiatry and Neurology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-510164
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Agrawal, Shyam Sunder& Gullaiya, Sumeet& Dubey, Vishal& Singh, Varun& Kumar, Ashok& Nagar, Ashish…[et al.]. Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats. Cardiovascular Psychiatry and Neurology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-510164
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-510164
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر